Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Abstract

Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (1–2) and dimeric peniphenylanes C–G (3–7), together with four known biogenetically related compounds (8–11) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC₅₀ = 9.3 µM).

Key words

Penicillium fellutanum - Trichocomaceae - 6-methylsaligenin - peniphenylanes - deep-sea-derived fungus - cytotoxic activity

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