Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Carola de la Guardia; Ada Virno; Maria Musumeci; Aude Bernardin; Michael B. Silberberg

doi:10.1055/s-0041-1741560

Facial Plastic Surgery, Table of Contents

CC BY-NC-ND 4.0 · Facial Plast Surg 2022; 38(02): 116-123
DOI: 10.1055/s-0041-1741560

Original Article

Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Carola de la Guardia

¹Medical Affairs, Allergan Aesthetics, an AbbVie company, Marlow, United Kingdom of Great Britain and Northern Ireland

,

Ada Virno

²Clinical Development, Allergan Aesthetics, an AbbVie company, Rome, Italy

,

Maria Musumeci

¹Medical Affairs, Allergan Aesthetics, an AbbVie company, Marlow, United Kingdom of Great Britain and Northern Ireland

,

Aude Bernardin

³Allergan Aesthetics, an AbbVie company, Pringy, France

,

Michael B. Silberberg

¹Medical Affairs, Allergan Aesthetics, an AbbVie company, Marlow, United Kingdom of Great Britain and Northern Ireland

› Author Affiliations

Abstract

Injections with hyaluronic acid (HA) fillers for facial rejuvenation and soft-tissue augmentation are among the most popular aesthetic procedures worldwide. Many HA fillers are available with unique manufacturing processes and distinct in vitro physicochemical and rheologic properties, which result in important differences in the fillers' clinical performance. The aim of this paper is to provide an overview of the properties most widely used to characterize HA fillers and to report their rheologic and physicochemical values obtained using standardized methodology to allow scientifically based comparisons. Understanding rheologic and physicochemical properties will guide clinicians in aligning HA characteristics to the facial area being treated for optimal clinical performance.

Keywords

aesthetics - hyaluronic acid fillers - elastic modulus - rheology

Full Text

References

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