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Semin Respir Crit Care Med 2021; 42(06): 839-858
DOI: 10.1055/s-0041-1740110
Review Article

COVID-19 in Immunocompromised Patients: A Systematic Review

Anna Stainer
1   Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
2   Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
,
Francesco Amati
1   Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
2   Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
,
Giulia Suigo
2   Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
,
Edoardo Simonetta
3   Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
4   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Respiratory Department, Milan, Italy
,
Andrea Gramegna
3   Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
4   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Respiratory Department, Milan, Italy
,
Antonio Voza
1   Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
5   Emergency Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
,
Stefano Aliberti
1   Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
2   Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
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Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first identified as a novel coronavirus in Wuhan, Hubei province, central China, in December 2019, and is responsible for the 2019-to-present pandemic. According to the most recent data released by the World Health Organization, more than 200 million people have been infected by SARS-CoV-2 so far, and more than 4 million people died worldwide. Although our knowledge on SARS-CoV-2 and COVID-19 is constantly growing, data on COVID-19 in immunocompromised patients are still limited. The aim of the present systematic review is to describe clinical picture, disease severity, proposed treatment regimen, and response to vaccination in patients with different types and severity of immunosuppression.

Keywords

COVID-19 - immunosuppression - SARS-CoV-2


Publication History

Article published online:
16 December 2021

© 2021. Thieme. All rights reserved.

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