Nickel-Catalyzed Regioselective Thiolation of Anilides with Thiols

Ebrahim Kianmehr; Fatemeh Doraghi; Alireza Foroumadi

doi:10.1055/s-0041-1737337

Synthesis, Table of Contents

Synthesis 2022; 54(10): 2464-2472
DOI: 10.1055/s-0041-1737337

paper

Nickel-Catalyzed Regioselective Thiolation of Anilides with Thiols

Authors

Ebrahim Kianmehr∗

^aSchool of Chemistry, College of Science, University of Tehran, Tehran 1417614411, Iran
Fatemeh Doraghi

^aSchool of Chemistry, College of Science, University of Tehran, Tehran 1417614411, Iran
Alireza Foroumadi∗

^bDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran

Abstract

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Abstract

An efficient method for direct thiolation of anilides with thiols using NiCl₂·6H₂O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway.

Key words

C–S cross-coupling - thiolation - nickel catalyst - acetanilides - thiols

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References

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Supplementary Material

Supporting Information (PDF)