Severity of Maternal SARS-CoV-2 Infection in Pregnancy Predicts Neonatal Outcomes

Abstract

Objective The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak had an enormous global impact. Pregnant women with SARS-CoV-2 appear to have higher morbidity and mortality. This study aimed to evaluate the effect of the severity of maternal SARS-CoV-2 infection on neonatal outcomes.

Study Design The clinical and laboratory data of 40 women and neonates evaluated retrospectively.

Results This retrospective study showed that SARS-CoV-2 infection had an adverse impact on neonatal outcomes proportionally with the maternal disease severity including increased prematurity rates, postnatal resuscitation need, prolonged hospital stay and longer ventilatory support requirement in infants born to mothers with moderate or severe disease.

Conclusion Maternal disease severity had adverse effects on neonatal outcomes. The severity of maternal disease was found to be associated with increased rates of prematurity, requirement of postnatal resuscitation, prolonged hospital stay, and longer ventilatory support.

Key Points

• SARS-CoV-2 pandemic is a problem for pregnant women.

• Vertical transmission has been shown in limited studies.

• Maternal disease severity may have impact on neonatal outcomes.

Keywords

SARS-CoV-2 infection - pregnancy - severity of COVID-19 disease - neonatal outcomes

Authors' Contributions

B.Y. and M.C. conceptualized and designed the study, and they also involved in data acquisition, analysis, and interpretation of data. S.M., D.Y.O., O.B., S.I.U., and I.P. were involved in acquisition and analysis of data. B.Y. drafted the article and M.C. finally approved the submitted version.

Note

Local ethical committee approval was obtained for the study (Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, approval no: 2021–21). The study was performed in accordance with the Declaration of Helsinki.

Publikationsverlauf

Eingereicht: 15. Mai 2021

Angenommen: 25. Juni 2021

Artikel online veröffentlicht:
28. Juli 2021

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