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CC BY 4.0 · Journal of Child Science 2021; 11(01): e133-e140
DOI: 10.1055/s-0041-1731077
Review Article

Current Treatment Guidelines of SARS-CoV-2 Related Multisystem Inflammatory Syndrome in Children: A Literature Review and Expert Opinion

Alireza Ghodsi 
1   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
,
Mehrdad Sarabi
1   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
,
Abdolreza Malek
2   Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
,
Ali Khakshour
2   Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
› Author Affiliations Funding None.
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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a systemic disorder that seems to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since April 2020, there have been multiple reports about children with this new condition worldwide, including Europe, Asia, Latin America, and North America. The symptoms of this syndrome mimic the clinical manifestations of Kawasaki disease; therefore, the treatment of Kawasaki disease, as well as supportive care, was the management of choice in children with MIS-C in the early days of recognizing it. It is important to precisely ascertain the risk of COVID-19 infection and its severity in children and to acknowledge the management of this syndrome, with reliable data from cohorts, trials, and experts' opinions. In the current review, we summarize the current management guidelines for MIS-C and present our own protocol to answer some clinical questions regarding MIS-C management during the COVID-19 pandemic.

Keywords

COVID-19 - SARS-CoV-2 - multisystem inflammatory syndrome in children - treatment - guideline


Publication History

Received: 04 February 2021

Accepted: 09 April 2021

Article published online:
22 June 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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