CC BY 4.0 · Pharmaceutical Fronts 2021; 03(01): e8-e12
DOI: 10.1055/s-0041-1730957
Original Article

Phenolic Constituents from the Stems of Morus nigra and their α-Glucosidase Inhibitory Activities

Ling-Ling Wang
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Liang-Jin Xu
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Meng-Jie Ma
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Chun-Yue Huang
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Tong Wu
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
,
Xiao Hu
1  State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
2  Shanghai Xinshengyuan Pharmaceutical Co., Ltd., Shanghai, People's Republic of China
› Author Affiliations
Funding This work was supported by the Natural Science Foundation of Shanghai (Grant No.19ZR1454400), the National Natural Science Foundation of China (Grant No. 81803844), and the National Science and Technology Major Project (Grant No. 2018ZX09731-016).

Abstracts

A new sanggenon-type flavanone, nigragenon F (1), together with 11 known compounds, trans-resveratrol (2), (E)-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene (3), notabilisin E (4), notabilisin A (5), morusin (6), petalopurpurenol (7), 8-geranyl-5,7-dihydroxycoumarin (8), 2,4-dihydroxybenzaldehyde (9), 4-ethoxy-2,6-dihydroxybenzoic acid (10), 3-hydroxy-4-methoxybenzaldehyde (11), and 4-hydroxybenzaldehyde (12), were isolated from the stems of Morus nigra. Compound 10 was a new natural product, compounds 3, 4, 7, and 8 were reported from the Morus genus for the first time. All of the isolated compounds were evaluated for their α-glucosidase inhibition activity. Among them, six compounds showed obvious inhibitory effects against α-glucosidase with IC50 values ranging from 1.24 to 19.00 µmol/L.

Supplementary Material



Publication History

Received: 02 February 2021

Accepted: 30 April 2021

Publication Date:
23 June 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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