Theory and Evidence for Platelet Therapy of the Aging Face

Arron M. Cole; Anthony P. Sclafani

doi:10.1055/s-0041-1725107

Facial Plastic Surgery, Table of Contents

Facial Plast Surg 2021; 37(02): 218-223
DOI: 10.1055/s-0041-1725107

Original Article

Theory and Evidence for Platelet Therapy of the Aging Face

Authors

Arron M. Cole

¹Otolaryngology Head and Neck Surgery, Weill Cornell Medicine, New York, New York
Anthony P. Sclafani

²Department of Otolaryngology, Head & Neck Surgery, Joan and Sanford I Weill Medical College of Cornell University, New York, New York

³Department of Facial Plastic Surgery, Center for Facial Plastic Surgery, Chappaqua, New York

Abstract

Platelet preparations are autologous blood concentrates with supraphysiologic concentrations of platelets with or without leukocytes used in various clinical applications including regenerative medicine, wound healing, and facial rejuvenation. Their use harnesses the important role of platelets and their secretory products in immunoregulation, wound healing, angiogenesis, and tissue remodeling. The use of platelet preparations has been long documented in orthopaedic surgery, maxillofacial surgery, and other fields, but over the years research has increased in their application to facial plastic surgical techniques. Here we review the various formulations of platelet rich concentrates, their applications to facial skin rejuvenation, wound healing, scar reduction, and tissue fill as documented in the literature since 2018.

Keywords

platelet - platelet rich plasma - platelet rich fibrin - facial rejuvenation - soft tissue volumization

Full Text

References

References
1 Hom DB. New developments in wound healing relevant to facial plastic surgery. Arch Facial Plast Surg 2008; 10 (06) 402-406
2 Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends in Biotechnology 2009; 27 (03) 158-167 ISSN 0167–7799
3 Wu PI, Diaz R, Borg-Stein J. Platelet-rich plasma. Phys Med Rehabil Clin N Am 2016; 27 (04) 825-853
4 Lana JF, Huber SC, Purita J. et al. Leukocyte-rich PRP versus leukocyte-poor PRP—the role of monocyte/macrophage function in the healing cascade. J Clin Orthop Trauma 2019; 10 (Suppl. 01) S7-S12
5 Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, Landesberg R. Differential growth factor retention by platelet-rich plasma composites. J Oral Maxillofac Surg 2005; 63 (04) 521-528
6 Karimi K, Rockwell H. The benefits of platelet-rich fibrin. Facial Plast Surg Clin North Am 2019; 27 (03) 331-340
7 Hersant B, SidAhmed-Mezi M, Picard F. et al. Efficacy of autologous platelet concentrates as adjuvant therapy to surgical excision in the treatment of keloid scars refractory to conventional treatments: a pilot prospective study. Ann Plast Surg 2018; 81 (02) 170-175
8 Bhargava S, Kroumpouzos G, Varma K, Kumar U. Combination therapy using subcision, needling, and platelet-rich plasma in the management of grade 4 atrophic acne scars: a pilot study. J Cosmet Dermatol 2019; 18 (04) 1092-1097
9 Hassan AS, El-Hawary MS, Abdel Raheem HM, Abdallah SH, El-Komy MM. Treatment of atrophic acne scars using autologous platelet-rich plasma vs combined subcision and autologous platelet-rich plasma: a split-face comparative study. J Cosmet Dermatol 2020; 19 (02) 456-461
10 Ibrahim MK, Ibrahim SM, Salem AM. Skin microneedling plus platelet-rich plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split face comparative study. J Dermatolog Treat 2018; 29 (03) 281-286
11 Min S, Yoon JY, Park SY, Moon J, Kwon HH, Suh DH. Combination of platelet rich plasma in fractional carbon dioxide laser treatment increased clinical efficacy of for acne scar by enhancement of collagen production and modulation of laser-induced inflammation. Lasers Surg Med 2018; 50 (04) 302-310
12 Galal O, Tawfik AA, Abdalla N, Soliman M. Fractional CO₂ laser versus combined platelet-rich plasma and fractional CO₂ laser in treatment of acne scars: image analysis system evaluation. J Cosmet Dermatol 2019; 18 (06) 1665-1671
13 Liao HT, Marra KG, Rubin JP. Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review. Tissue Eng Part B Rev 2014; 20 (04) 267-276
14 Smith OJ, Jell G, Mosahebi A. The use of fat grafting and platelet-rich plasma for wound healing: a review of the current evidence. Int Wound J 2019; 16 (01) 275-28
15 Willemsen JCN, Van Dongen J, Spiekman M. et al. the addition of platelet-rich plasma to facial lipofilling: a double-blind, placebo-controlled, randomized trial. Plast Reconstr Surg 2018; 141 (02) 331-343
16 Sasaki GH. A preliminary clinical trial comparing split treatments to the face and hand with autologous fat grafting and platelet-rich plasma (PRP): a 3D, IRB-approved study. Aesthet Surg J 2019; 39 (06) 675-686
17 Menchisheva Y, Mirzakulova U, Yui R. Use of platelet-rich plasma to facilitate wound healing. Int Wound J 2019; 16 (02) 343-353
18 Yuliya M, Ulmeken M. Effects of platelet-rich plasma on aesthetic outcomes of maxillofacial surgical procedures. Dermatol Surg 2020; 46 (02) 283-286
19 Gode S, Ozturk A, Berber V, Kısmalı E. Effect of injectable platelet-rich fibrin on diced cartilage's viability in rhinoplasty. Facial Plast Surg 2019; 35 (04) 393-396
20 Parra F, Morales-Rome DE, Campos-Rodríguez R, Cruz-Hernández TR, Drago-Serrano ME. Effect of platelet-rich plasma on patients after blepharoplasty surgery. Orbit 2018; 37 (02) 81-86
21 Slaninka I, Fibír A, Kaška M, Páral J. Use of autologous platelet-rich plasma in healing skin graft donor sites. J Wound Care 2020; 29 (01) 36-41
22 Fang Z, Yang X, Wu G. et al. The use of autologous platelet-rich plasma gel increases wound healing and reduces scar development in split-thickness skin graft donor sites. J Plast Surg Hand Surg 2019; 53 (06) 356-360
23 Everts PA, Pinto PC, Girão L. Autologous pure platelet-rich plasma injections for facial skin rejuvenation: biometric instrumental evaluations and patient-reported outcomes to support antiaging effects. J Cosmet Dermatol 2019; 18 (04) 985-995
24 Nacopoulos C, Vesala AM. Lower facial regeneration with a combination of platelet-rich fibrin liquid matrices based on the low speed centrifugation concept-Cleopatra technique. J Cosmet Dermatol 2020; 19 (01) 185-189
25 Hofny ERM, Abdel-Motaleb AA, Ghazally A, Ahmed AM, Hussein MRA. Platelet-rich plasma is a useful therapeutic option in melasma. J Dermatolog Treat 2019; 30 (04) 396-401
26 Hofny ERM, Hussein MRA, Ghazally A, Ahmed AM, Abdel-Motaleb AA. Increased expression of TGF-β protein in the lesional skins of melasma patients following treatment with platelet-rich plasma. J Cosmet Laser Ther 2019; 21 (7-8): 382-389
27 Abdelghani R, Ahmed NA, Darwish HM. Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: a prospective, randomized comparative trial. J Cosmet Dermatol 2018; 17 (03) 365-372
28 El-Domyati M, Abdel-Wahab H, Hossam A. Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split-face comparative study. Int J Dermatol 2018; 57 (11) 1324-1334
29 Nofal E, Elkot R, Nofal A, Eldesoky F, Shehata S, Sami M. Evaluation of carboxytherapy and platelet-rich plasma in treatment of periorbital hyperpigmentation: a comparative clinical trial. J Cosmet Dermatol 2018; 17 (06) 1000-1007
30 Ellabban NF, Eyada M, Nada H, Kamel N. Efficacy and tolerability of using platelet-rich plasma versus chemical peeling in periorbital hyperpigmentation. J Cosmet Dermatol 2019; 18 (06) 1680-1685