Endoscopy 2021; 53(S 01): S230
DOI: 10.1055/s-0041-1724899
Abstracts | ESGE Days
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The Impact Of Endoscopic Ultrasound Guided Fine-Needle Biopsy (EUS-FNB) In The Evaluation Of Non-Pancreatic Solid Lesions Of Upper Gastrointestinal Tract And Mediastinum

I Budimir
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
,
T Pavić
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
,
N Baršić
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
,
M Živković
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
,
Z Juroš
2   «SestreMilosrdnice» University Hospital Center, Department of Pathology, Zagreb, Croatia
,
V Ratkajec
3   County Hospital Virovitica, Virovitica, Croatia
,
A Ratković
4   County Hospital Gospić, Gospić, Croatia
,
D Bakula
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
,
D Hrabar
1   «SestreMilosrdnice» University Hospital Center, Division of Gastroenterology, Department of Internal Medicine, Zagreb, Croatia
› Author Affiliations
 

Aims This prospective study highlights diagnostic accuracy and complications of EUS-FNB focusing on non-pancreatic solid lesions.

Methods Between January 2019 and June 2020, 46 adult patients with mediastinal, oesophagal, gastric, duodenal, liver, biliary and retroperitoneal solid lesions were prospectively observed. Exclusion criteria were cystic lesions and absolute contraindications to FNB. Sedation was performed by intravenous administration of midazolam and fentanyl. EUS-FNB (transesophageal, transgastric or transduodenal approach) was performed using an ultrasound endoscope and 22-gauge Boston scientific Acquire needle (2-3 time passes; low negative pressure). All collected specimens were sent for cytological and histopathological analysis. EUS-FNB samples were adequate for histological analysis in nine (19,5 %) patients because of that we didn’t make a statistic pattern. In the case of EUS-FNB of the lymph node, a flow-cytometry analysis was used. The primary endpoints were diagnostic sensitivity and specificity of EUS-FNB for non-pancreatic solid lesions. The second endpoint was the frequency of EUS-FNB complications.

Results 45,6 % of patients were under the age of 65. 51 % of the patients were women. Most of the lesions were in lymph nodes (13;28.3 %), biliary tree (10;21.7 %), liver (6;13 %), mediastinum (9;19.6 %) and retroperitoneum (7;15.2 %). The final diagnosis revealed malignancy in 41 cases (GISTs, adenocarcinomas, melanomas) (78.3 %), lymphomas (10.9 %). Benign tumours (adenomas, leiomyomas) were confirmed in three (6.5 %), and granulomatosis in two (4.6 %) patients. Sensitivity, specificity, positive and negative predictive values of EUS-FNB (based on cytological analysis) for diagnosing extrapancreatic tumors were 94.59 % (95 %CI; 81.81 % to 99.34 %), 83.33 % (95 % CI; 35.88 % to 99.58 %), 97.22 % (95 % CI; 85.38 % to 99.53 %, 71.43 % (95 % CI; 38.26 % to 90.98 %), respectively. There were no major complications.

Conclusions EUS-FNB is an extremely sensitive modality that enables specific and accurate diagnosis of non-pancreatic solid lesions of the upper gastrointestinal tract and mediastinum. When EUS-FNB is performed by an experienced endoscopist there is a low rate of complications.

Citation Budimir I, Pavić T, Baršić N et al. eP408 THE IMPACT OF ENDOSCOPIC ULTRASOUND GUIDED FINE-NEEDLE BIOPSY (EUS-FNB) IN THE EVALUATION OF NON-PANCREATIC SOLID LESIONS OF UPPER GASTROINTESTINAL TRACT AND MEDIASTINUM. Endoscopy 2021; 53: S230.



Publication History

Article published online:
19 March 2021

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