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Management of Leukemia and Partial Atrioventricular Septal Defect during Pregnancy
Background Pregnancy-associated acute myeloid leukemia (PA-AML) is rare. Cardiac surgery in the context of AML poses challenges that are seldom encountered.
Case Description The subject is a 31-year-old woman at 38 weeks' gestational age diagnosed with AML and partial atrioventricular septal defect. After multidisciplinary consulting, an urgent cesarean section was performed, then chemotherapy was initiated, followed by minimally invasive cardiac surgery with an uneventful recovery.
Conclusion Efficient multidisciplinary approach is essential in the management of PA-AML and cardiac disease. Minimally invasive cardiac surgery may be safe and useful in patients with AML.
Received: 09 September 2020
Accepted: 16 November 2020
28 June 2021 (online)
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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- 1 Horowitz NA, Henig I, Henig O, Benyamini N, Vidal L, Avivi I. Acute myeloid leukemia during pregnancy: a systematic review and meta-analysis. Leuk Lymphoma 2018; 59 (03) 610-616
- 2 Lindley KJ, Conner SN, Cahill AG. Adult congenital heart disease in pregnancy. Obstet Gynecol Surv 2015; 70 (06) 397-407
- 3 Martin S, Arafeh J. Cardiac disease in pregnancy. AACN Adv Crit Care 2018; 29 (03) 295-302
- 4 Ali S, Jones GL, Culligan DJ. et al; British Committee for Standards in Haematology. Guidelines for the diagnosis and management of acute myeloid leukaemia in pregnancy. Br J Haematol 2015; 170 (04) 487-495
- 5 Guler A, Sahin MA, Cingoz F, Ozal E, Demirkilic U, Arslan M. Can cardiac surgery be performed safely on patients with haematological malignancies. Cardiovasc J Afr 2012; 23 (04) 194-196
- 6 Langer NB, Argenziano M. Minimally invasive cardiovascular surgery: incisions and approaches. Methodist DeBakey Cardiovasc J 2016; 12 (01) 4-9
- 7 Paparella D, Rotunno C, Guida P. et al. Minimally invasive heart valve surgery: influence on coagulation and inflammatory response. Interact Cardiovasc Thorac Surg 2017; 25 (02) 225-232
- 8 Gao C, Yang M, Xiao C, Zhang H. Totally robotic repair of atrioventricular septal defect in the adult. J Cardiothorac Surg 2015; 10: 156