Positive Effekte auf den Insulinbedarf – Überzeugende Daten zu Sitagliptin

Mit ihrer Forderung nach kardiovaskulären Endpunktstudien haben die US-amerikanische und die europäische Zulassungsbehörde die kardiovaskuläre Sicherheit antidiabetischer Therapiestrategien in den Fokus des Interesses gerückt [ 1 ], [ 2 ]. Dem hat der Dipeptidylpeptidase-4-Inhibitor (DPP-4-Hemmer) Sitagliptin mit der Präsentation der TECOS[ ¹ ]-Studiendaten [ 3 ] Anfang Juni dieses Jahres auf dem Kongress der „American Diabetes Association“ Rechnung getragen – und seine kardiovaskuläre Sicherheit belegt.

• Literatur

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• 2 European Medicine Agency, Committee for Medicinal Products for Human Use, Guideline on clinical investigation of medicinal products in the treatment of diabetes mellitus. 01/2010 www.ema.europa.eu/docs/en_GB/dicument_library/Scientific_guideline/2010/02/WC500073570.pdf
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