J Knee Surg 2022; 35(09): 971-977
DOI: 10.1055/s-0040-1721126
Original Article

National Decline in Knee Fusions Performed for Salvage of Chronic Periprosthetic Total Knee Infections

Sean S. Rajaee
1   Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, California
,
Joseph J. Kavolus
2   Department of Orthopaedic Surgery, Tufts Medical Center, Boston, Massachusetts
,
Brett L. Hayden
3   Department of Orthopaedic Surgery, Mount Sinai, New York, New York
,
Daniel M. Estok
4   Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
Funding None.

Abstract

The primary purpose of this study was to study and compare rates of two salvage operations for patients with chronically infected total knee arthroplasties: (1) knee arthrodesis and (2) above knee amputation (AKA). An analysis was performed comparing the inpatient hospital characteristics and complications between the two procedures. Secondarily, we presented rates of all surgically treated periprosthetic total knee infections over a 6-year period. Using the Nationwide Inpatient Sample, we identified all patients with a periprosthetic infection (International Classification of Diseases, Ninth Revision [ICD-9] 996.66) from 2009 to 2014. Subsequently, we identified surgically treated total knee infections through the following ICD-9 codes: 00.80 (all component revision), 00.84 (liner exchange), 80.06 (removal of prosthesis), 84.17 (AKA), and 81.22 (knee fusion). From 2009 to 2014, the annual incidence of surgically treated total knee periprosthetic infections increased by 34.9% nationally, while the annual incidence of primary total knees increased by only 13.9%. Salvage operations (AKA and knee fusion) represented 5.8% of all surgically treated infections. The rate of knee fusions decreased from 1.9% of surgically treated infections in 2009 to 1.4% in 2014 (p < 0.05), while the rate of AKA stayed steady at 4.5% of cases over the 6-year period. Length of stay was significantly shorter in the knee fusion group (7.9 vs. 10.8 days, p < 0.05), but total hospital costs were higher (33,016 vs. 24,933, p < 0.05). In the multivariable adjusted model, patients undergoing knee fusion had significantly decreased odds of being discharged to skilled nursing facility (odds ratio: 0.42, 95% confidence interval: 0.31–0.58). The annual incidence of surgically treated periprosthetic total knee infections is increasing. The rate of knee arthrodesis for chronic periprosthetic total knee infections is decreasing. Reasons for this downward trend in knee fusions should be evaluated carefully as knee fusions have shown to have the potential advantage of improved mobility and decreased patient morbidity for chronic PJI. The level of evidence is III.



Publication History

Received: 14 May 2020

Accepted: 11 October 2020

Article published online:
03 January 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Bozic KJ, Kurtz SM, Lau E. et al. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 2010; 468 (01) 45-51
  • 2 Kubista B, Hartzler RU, Wood CM, Osmon DR, Hanssen AD, Lewallen DG. Reinfection after two-stage revision for periprosthetic infection of total knee arthroplasty. Int Orthop 2012; 36 (01) 65-71
  • 3 Mortazavi SM, Vegari D, Ho A, Zmistowski B, Parvizi J. Two-stage exchange arthroplasty for infected total knee arthroplasty: predictors of failure. Clin Orthop Relat Res 2011; 469 (11) 3049-3054
  • 4 Mittal Y, Fehring TK, Hanssen A, Marculescu C, Odum SM, Osmon D. Two-stage reimplantation for periprosthetic knee infection involving resistant organisms. J Bone Joint Surg Am 2007; 89 (06) 1227-1231
  • 5 Mahmud T, Lyons MC, Naudie DD, Macdonald SJ, McCalden RW. Assessing the gold standard: a review of 253 two-stage revisions for infected TKA. Clin Orthop Relat Res 2012; 470 (10) 2730-2736
  • 6 Wu CH, Gray CF, Lee GC. Arthrodesis should be strongly considered after failed two-stage reimplantation TKA. Clin Orthop Relat Res 2014; 472 (11) 3295-3304
  • 7 Scott SJ, Hennessey MS, Parkinson RW, Molloy AP. Long-term outcome of the 'Beefburger' procedure in patients unsuitable for two-stage revision following infected total knee replacement. Knee 2001; 8 (04) 281-286
  • 8 Sierra RJ, Trousdale RT, Pagnano MW. Above-the-knee amputation after a total knee replacement: prevalence, etiology, and functional outcome. J Bone Joint Surg Am 2003; 85 (06) 1000-1004
  • 9 Pring DJ, Marks L, Angel JC. Mobility after amputation for failed knee replacement. J Bone Joint Surg Br 1988; 70 (05) 770-771
  • 10 Angelini A, Henderson E, Trovarelli G, Ruggieri P. Is there a role for knee arthrodesis with modular endoprostheses for tumor and revision of failed endoprostheses?. Clin Orthop Relat Res 2013; 471 (10) 3326-3335
  • 11 Hak DJ, Lieberman JR, Finerman GA. Single plane and biplane external fixators for knee arthrodesis. Clin Orthop Relat Res 1995; (316) 134-144
  • 12 Waldman BJ, Mont MA, Payman KR. et al. Infected total knee arthroplasty treated with arthrodesis using a modular nail. Clin Orthop Relat Res 1999; (367) 230-237
  • 13 Puranen J, Kortelainen P, Jalovaara P. Arthrodesis of the knee with intramedullary nail fixation. J Bone Joint Surg Am 1990; 72 (03) 433-442
  • 14 Kuo AC, Meehan JP, Lee M. Knee fusion using dual platings with the locking compression plate. J Arthroplasty 2005; 20 (06) 772-776
  • 15 Chen AF, Kinback NC, Heyl AE, McClain EJ, Klatt BA. Better function for fusions versus above-the-knee amputations for recurrent periprosthetic knee infection. Clin Orthop Relat Res 2012; 470 (10) 2737-2745
  • 16 Conway JD, Mont MA, Bezwada HP. Arthrodesis of the knee. J Bone Joint Surg Am 2004; 86 (04) 835-848
  • 17 Introduction the the HCUP NIS National Inpatient Sample. Published 2016. Accessed 2016 at: https://www.hcup-us.ahrq.gov/db/nation/nis/NISIntroduction2014.pdf
  • 18 Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care 1998; 36 (01) 8-27
  • 19 Röhner E, Windisch C, Nuetzmann K, Rau M, Arnhold M, Matziolis G. Unsatisfactory outcome of arthrodesis performed after septic failure of revision total knee arthroplasty. J Bone Joint Surg Am 2015; 97 (04) 298-301
  • 20 Hungerer S, Kiechle M, von Rüden C, Militz M, Beitzel K, Morgenstern M. Knee arthrodesis versus above-the-knee amputation after septic failure of revision total knee arthroplasty: comparison of functional outcome and complication rates. BMC Musculoskelet Disord 2017; 18 (01) 443
  • 21 Rud B, Jensen UH. Function after arthrodesis of the knee. Acta Orthop Scand 1985; 56 (04) 337-339
  • 22 Enneking WF, Shirley PD. Resection-arthrodesis for malignant and potentially malignant lesions about the knee using an intramedullary rod and local bone grafts. J Bone Joint Surg Am 1977; 59 (02) 223-236
  • 23 Isiklar ZU, Landon GC, Tullos HS. Amputation after failed total knee arthroplasty. Clin Orthop Relat Res 1994; (299) 173-178
  • 24 Enquist M, Bosco III JA, Pazand L, Habibi KA, Donoghue RJ, Zuckerman JD. Managing episodes of care: strategies for orthopaedic surgeons in the era of reform. J Bone Joint Surg Am 2011; 93 (10) e55
  • 25 Patel AA, Singh K, Nunley RM, Minhas SV. Administrative databases in orthopaedic research: pearls and pitfalls of big data. J Am Acad Orthop Surg 2016; 24 (03) 172-179
  • 26 Lau EC, Son MS, Mossad D. et al. The validity of administrative BMI data in total joint arthroplasty. J Arthroplasty 2015; 30 (10) 1683-1687
  • 27 Trofa D, Rajaee SS, Smith EL. Nationwide trends in total shoulder arthroplasty and hemiarthroplasty for osteoarthritis. Am J Orthop 2014; 43 (04) 166-172
  • 28 Schraufnagel D, Rajaee S, Millham FH. How many sunsets? Timing of surgery in adhesive small bowel obstruction: a study of the Nationwide Inpatient Sample. J Trauma Acute Care Surg 2013; 74 (01) 181-187 , discussion 187–189
  • 29 Rajaee SS, Campbell JC, Mirocha J, Paiement GD. Increasing burden of total hip arthroplasty revisions in patients between 45 and 64 years of age. J Bone Joint Surg Am 2018; 100 (06) 449-458
  • 30 Rajaee SS, Theriault RV, Pevear ME, Smith EL. National trends in primary total hip arthroplasty in extremely young patients: a focus on bearing surface usage from 2009 to 2012. J Arthroplasty 2016; 31 (9, Suppl): 63-68
  • 31 Rajaee SS, Kanim LE, Bae HW. National trends in revision spinal fusion in the USA: patient characteristics and complications. Bone Joint J 2014; 96-B (06) 807-816
  • 32 Rajaee SS, Bae HW, Kanim LE, Delamarter RB. Spinal fusion in the United States: analysis of trends from 1998 to 2008. Spine 2012; 37 (01) 67-76
  • 33 Bohl DD, Russo GS, Basques BA. et al. Variations in data collection methods between national databases affect study results: a comparison of the Nationwide Inpatient Sample and National Surgical Quality Improvement Program databases for lumbar spine fusion procedures. J Bone Joint Surg Am 2014; 96 (23) e193
  • 34 Bohl DD, Basques BA, Golinvaux NS, Baumgaertner MR, Grauer JN. Nationwide Inpatient Sample and National Surgical Quality Improvement Program give different results in hip fracture studies. Clin Orthop Relat Res 2014; 472 (06) 1672-1680