CIN2+ diagnoses between 2013 and 2018 in women 18 to 45 years old – Results from a German statutory health insurance claims data analysis

Objectives Cervical intraepithelial neoplasia (CIN) can result from Human Papillomavirus (HPV) infection, can present considerable burden to patients (surgical procedures/psychosocial consequences) and may be prevented by HPV vaccination. The objective was to estimate the 2013-2018 annual proportion of women 18-45 years-old with CIN2+ diagnoses in Germany.

Methods We conducted a retrospective cross-sectional claims data analysis using the Institute for Applied Health Research Berlin (InGef) Database, representative of the German population regarding age and gender. The annual proportion (2013-2018) of 18-45 year-olds with CIN2+ diagnoses was calculated as number of women with at least one respective ICD-10-GM record divided by the total number of women in the database.

Results The overall proportion of women 18-45 years-old with CIN2+ diagnoses was 7.9/1,000, 8.2/1,000, 7.7/1,000, 7.2/1,000, 7.0/1,000, and 6.7/1,000 in 2013, 2014, 2015, 2016, 2017, and 2018, respectively. Women 31-35 years-old accounted for 23.2 % and 28.3 % of CIN2+ diagnoses in 2013 and 2018, respectively. The proportion of 20-26-year-old women with CIN2+ diagnoses was 6.3/1,000 and 3.4/1,000 in 2013 and 2018, respectively (Figure 1).

Conclusions The burden of CIN2+ diagnosis in women >30 years remains substantial. Changes in CIN2+ diagnoses 2013-2018 could be driven by changes in HPV vaccination, behavior, and screening patterns.

Annual proportion of women with CIN2+ diagnosis by age groups in Germany from 2013-2018.

Publikationsverlauf

Artikel online veröffentlicht:
07. Oktober 2020