CC BY-NC-ND 4.0 · Journal of Child Science 2020; 10(01): e104-e109
DOI: 10.1055/s-0040-1716713
Review Article

Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

Antonio Molina-Carballo
1  Department of Pediatrics, Unit of Pediatric Neurology and Neurodevelopment, Clínico San Cecilio University Hospital, the Andalusian Health Service, School of Medicine, University of Granada, Granada, Spain
,
Antonio Emilio Jerez-Calero
1  Department of Pediatrics, Unit of Pediatric Neurology and Neurodevelopment, Clínico San Cecilio University Hospital, the Andalusian Health Service, School of Medicine, University of Granada, Granada, Spain
,
Antonio Muñoz-Hoyos
1  Department of Pediatrics, Unit of Pediatric Neurology and Neurodevelopment, Clínico San Cecilio University Hospital, the Andalusian Health Service, School of Medicine, University of Granada, Granada, Spain
› Author Affiliations
  

Abstract

Melatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.



Publication History

Received: 06 June 2020

Accepted: 07 August 2020

Publication Date:
23 September 2020 (online)

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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