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Semin Respir Crit Care Med 2020; 41(03): 377-385
DOI: 10.1055/s-0040-1712099
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The State of the Science in Patient-Reported Outcomes for Patients with Lung Cancer

Canhua Xiao
1   Smilow Cancer Hospital Care Center, Yale School of Nursing, Orange, Connecticut
,
Newton Hurst
2   Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan
,
Benjamin Movsas
2   Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan
› Author Affiliations
Further Information

Publication History

Publication Date:
25 May 2020 (online)

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Abstract

Traditionally, clinicians have assumed the primary responsibility for evaluating disease- and treatment-related outcomes. In the past few decades, however, a series of recommendations and standards promulgated by professional societies and regulatory agencies have resulted in increased use of patient-reported outcome (PRO) measures in cancer clinical trials. PROs, such as quality of life (QOL) measures, are important in establishing overall treatment effectiveness in cancer clinical trials, and they can inform clinical decision making. This article discusses the current state of the science in PRO research for patients with lung cancer, the cancer type with the highest incidence rate and the lowest survival rate worldwide. The discussion focuses on (1) PRO and survival; (2) electronic PRO reporting and interventions; (3) PROs and immunotherapy; (4) PRO, biomarkers, and precision health; (5) key issues in applying PROs in clinical trials; and (6) future directions for research.

Keywords

lung cancer - patient-reported outcomes - quality of life
 

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