Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection

Abstract

Novel coronavirus disease 2019 (COVID-19) infection occurring during pregnancy is associated with an increased risk of preterm delivery. This case report describes successful treatment of preterm labor during acute COVID-19 infection. Standard treatment for preterm labor may allow patients with acute COVID-19 infection to recover without the need for preterm delivery.

Key Points

• Acute COVID-19 infection is associated with a high rate of preterm delivery.

• Standard treatment for preterm labor such as intravenous magnesium sulfate, antepartum steroid therapy and antibiotic prophylaxis for group B streptococcus infection were effective in this patient.

• In the absence of maternal or fetal compromise, acute COVID-19 infection is not an indication for early elective delivery.

Keywords

COVID-19 - coronavirus - pregnancy - pregnancy complication - preterm labor - azithromycin

• References

• 1 Meijer WJ, van Noortwijk AG, Bruinse HW, Wensing AM. Influenza virus infection in pregnancy: a review. Acta Obstet Gynecol Scand 2015; 94 (08) 797-819
• 2 Theiler RN, Rasmussen SA, Treadwell TA, Jamieson DJ. Emerging and zoonotic infections in women. Infect Dis Clin North Am 2008; 22 (04) 755-772
• 3 Nunes MC, Aqil AR, Omer SB, Madhi SA. The effects of influenza vaccination during pregnancy on birth outcomes: a systematic review and meta-analysis. Am J Perinatol 2016; 33 (11) 1104-1114
• 4 Cao Y, Liu X, Xiong L, Cai K. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. J Med Virol 2020 (e-pub ahead of print) Doi: 10.1002/jmv.25822
• 5 Mullins E, Evans D, Viner RM, O'Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol 2020 (e-pub ahead of print) Doi: 10.1002/uog.22014
• 6 Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal Coronavirus infections and pregnancy outcomes. Arch Path Lab Med 2020 Doi: 10.5858/arpa.2020-0901-SA
• 7 Centers for Disease Control and Prevention. Information for clinicians on therapeutic options for COVID-19 patients. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html . Accessed April 8, 2020
• 8 Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. ; HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395 (10229): 1033-1034