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CC BY-NC-ND 4.0 · AJP Rep 2020; 10(02): e159-e164
DOI: 10.1055/s-0040-1709983
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Risk Factors for Postpartum Maternal Infection Following Spontaneous Vaginal Delivery Complicated by Chorioamnionitis

Helen A. Daifotis 
1   Duke University School of Medicine, Durham, North Carolina
,
Megan M. Smith
1   Duke University School of Medicine, Durham, North Carolina
,
Anna E. Denoble
2   Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
,
Sarah K. Dotters-Katz
2   Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
› Author Affiliations
Further Information

Publication History

08 September 2019

05 March 2020

Publication Date:
15 May 2020 (online)

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Abstract

Objective Guidelines for the management of chorioamnionitis include intrapartum antibiotics, while postpartum antibiotics after spontaneous vaginal delivery (SVD) are reserved high-risk women. Our objective is to describe the incidence of and risk factors for postpartum infection after SVD complicated by chorioamnionitis.

Study Design This is a retrospective study of SVDs with clinically diagnosed chorioamnionitis at a single center. The primary outcome was a composite of postpartum infection. Women who developed the primary outcome were compared with those who did not using bivariate statistics. Regression models were developed to estimate adjusted odds of outcomes.

Results In this cohort, 346 women underwent SVD complicated by chorioamnionitis. Of these, 23 (6.6%) developed postpartum infections (endometritis n = 7, urinary tract infection/pyelonephritis n = 6, sepsis n = 4, and perineal wound infection n = 6). Receipt of antibiotics intra- or postpartum did not differ between groups, but women with postpartum infections were more likely to deliver prior to 32 weeks (17.4 vs. 4.9%, p = 0.04). When controlling for antibiotic use, delivery at < 32 weeks was associated with 3.8-fold increased (95% confidence interval: 1.07–13.7) odds of postpartum infection.

Conclusion Postpartum infections occur in ∼1/15 women delivering vaginally with chorioamnionitis, with those who deliver at < 32 weeks' gestation being at increased risk.

Keywords

chorioamnionitis - intrapartum antibiotics - postpartum antibiotics - maternal morbidity - postpartum infection - preterm delivery - spontaneous vaginal delivery

Financial Support

None.


Meeting Presentation Disclosure

These data were presented in part as a poster presentation at the American College of Obstetricians and Gynecologists Annual Clinical and Scientific Meeting, May 2–5, 2019, in Nashville, TN.


 

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