PDF herunterladen
CC BY 4.0 · Journal of Child Science 2020; 10(01): e16-e20
DOI: 10.1055/s-0040-1709718
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Arterial Blood Lactate in Children Primarily Submitted to Noninvasive Ventilation: A Time-Dependent ROC Analysis

Lactate and noninvasive ventilation in children
Luciana S. M. Luz 
1   Mother and Child Department, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil
,
Andre Ricardo Araujo Silva 
2   Mother and Child Department, Department of Pediatrics, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil
,
Cristina Ortiz Sobrinho Valete 
2   Mother and Child Department, Department of Pediatrics, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil
› Institutsangaben
Weitere Informationen

Publikationsverlauf

14. November 2019

06. März 2020

Publikationsdatum:
18. April 2020 (online)

Auch verfügbar auf
   Lizenzen und Reprints

Abstract

The purpose of this study was to evaluate blood lactate measurements and failure to noninvasive ventilation (NIV) in children admitted to a pediatric intensive care unit. This was a retrospective observational single-center study performed between June 2016 and June 2017. Dynamic lactate indices and failure to NIV in 63 children < 18 years and > 1 month old were examined; we considered blood lactate analyses at time 0, 6, 24, and 48 hours. NIV failure group had a higher pediatric risk of mortality (PRISM) score. Lactate indices decreased over time in the success group (p < 0.001). The best area under the curve observed was 69%, at 48 hours. Considering all measurements, the area under the curve for time-dependent receiver-operating characteristic curve was 58.6%. This study demonstrated blood lactate indices evolution over time in children submitted to NIV.

Keywords

lactate - child - critical care - ROC curve

Authors' Contributions

C.O.S.V. was involved in analyzing data and writing the original research, and agreed to the final manuscript. L.S.M.L. and A.R.A.S. were involved in data collection, critical review, obtained ethical approval, and approved the final manuscript.


 

  • References

  • 1 Mayordomo-Colunga J, Pons M, López Y. , et al. Predicting non-invasive ventilation failure in children from the SpO2/FiO2 (SF) ratio. Intensive Care Med 2013; 39 (06) 1095-1103
    CrossrefPubMedGoogle Scholar
  • 2 Yaman A, Kendirli T, Ödek Ç. , et al. Efficacy of noninvasive mechanical ventilation in prevention of intubation and reintubation in the pediatric intensive care unit. J Crit Care 2016; 32: 175-181
    CrossrefPubMedGoogle Scholar
  • 3 Mayordomo-Colunga J, Medina A, Rey C. , et al. Predictive factors of noninvasive ventilation failure in critically ill children: a prospective epidemiological study. Intensive Care Med 2009; 35 (03) 527-536
    CrossrefPubMedGoogle Scholar
  • 4 Nichol A, Bailey M, Egi M. , et al. Dynamic lactate indices as predictors of outcome in critically ill patients. Crit Care 2011; 15 (05) R242
    CrossrefPubMedGoogle Scholar
  • 5 Yang L, Fan Y, Lin R, He W. Blood lactate as a reliable marker for mortality of pediatric refractory cardiogenic shock requiring extracorporeal membrane oxygenation. Pediatr Cardiol 2019; 40 (03) 602-609
    CrossrefPubMedGoogle Scholar
  • 6 Cerezuela-Espejo V, Courel-Ibáñez J, Morán-Navarro R, Martínez-Cava A, Pallarés JG. The relationship between lactate and ventilatory thresholds in runners: validity and reliability of exercise test performance parameters. Front Physiol 2018; 9: 1320
    Google Scholar
  • 7 Robergs RA, Ghiasvand F, Parker D. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 2004; 287 (03) R502-R516
    CrossrefPubMedGoogle Scholar
  • 8 Khan T, Lundgren LE, Järpe E, Olsson MC, Viberg P. A Novel Method for Classification of Running Fatigue Using Change-Point Segmentation. Sensors (Basel) 2019; 19(21):E4729
    PubMed
  • 9 Goldstein B, Giroir B, Randolph A. ; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6 (01) 2-8
    CrossrefPubMedGoogle Scholar
  • 10 Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated pediatric risk of mortality score. Crit Care Med 1996; 24 (05) 743-752
    CrossrefPubMedGoogle Scholar
  • 11 Desplanque L, Hamaide-Defrocourt F, Berkia I, Tourneur T, Albinni S, Bojan M. Lactate clearance in infants undergoing surgery for congenital heart disease. Artif Organs 2019; 43 (01) 54-59
    CrossrefPubMedGoogle Scholar
  • 12 Kamarudin AN, Cox T, Kolamunnage-Dona R. Time-dependent ROC curve analysis in medical research: current methods and applications. BMC Med Res Methodol 2017; 17 (01) 53
    CrossrefPubMedGoogle Scholar
  • 13 Bakalli I, Celaj E, Simaku A, Kola E, Sallabanda S. Predictors of noninvasive ventilation success in children with acute respiratory failure. Intensive Care Med 2015; 41 (05) 950-951
    CrossrefPubMedGoogle Scholar
  • 14 James CS, Hallewell CP, James DP, Wade A, Mok QQ. Predicting the success of non-invasive ventilation in preventing intubation and re-intubation in the paediatric intensive care unit. Intensive Care Med 2011; 37 (12) 1994-2001
    CrossrefPubMedGoogle Scholar
  • 15 Antonelli M, Conti G, Moro ML. , et al. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 2001; 27 (11) 1718-1728
    CrossrefPubMedGoogle Scholar
  • 16 Antonelli M, Conti G, Esquinas A. , et al. A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med 2007; 35 (01) 18-25
    CrossrefPubMedGoogle Scholar
  • 17 Essouri S, Chevret L, Durand P, Haas V, Fauroux B, Devictor D. Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med 2006; 7 (04) 329-334
    CrossrefPubMedGoogle Scholar
  • 18 Lins ARBDS, Duarte MDCMB, Andrade LB. Noninvasive ventilation as the first choice of ventilatory support in children. Rev Bras Ter Intensiva 2019; 31 (03) 333-339
    PubMedGoogle Scholar