Dedicated to Prof. Dr. Kye Chun Nam on the occasion of his 65th birthday.
Abstract
Alkynoic acids have been widely employed as alkyne and alkene sources in decarboxylative
reactions. Alkynoic acid coupling leads to the formation of direct coupling products
and cyclized products through sequential reactions. Moreover, homocoupling and multicomponent
reactions have been developed. The decarboxylative addition of alkynoic acids generates
the corresponding alkene products. A number of synthetic methods are utilized for
the preparation of arylpropynoic acids including the Sonogashira coupling and the
carboxylation of terminal alkynes. Recently, the use of decarboxylative halogenations
has also been reported. This review covers decarboxylative reactions of alkynoic acids
reported between 2013 and 2019; further, it is divided into several sections according
to the type of reaction.
1 Introduction
2 Direct Coupling
3 Sequential Reactions
4 Homocoupling
5 Multicomponent Reactions
6 Addition
7 Halogenations
8 Synthesis of Alkynoic Acids
9 Conclusion
Key words
alkynoic acid - decarboxylative coupling - propynoic acid - transition-metal catalyst
- alkyne
