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CC BY-NC-ND 4.0 · SynOpen 2020; 04(02): 17-22
DOI: 10.1055/s-0040-1707517
DOI: 10.1055/s-0040-1707517
paper
Aerobic Iron(III)-Catalyzed Direct Thiolation of Imidazo[1,2-a]pyridine with Thiols
Funding was provided by the Natural Science Foundation of Guangdong Province (2017A030310021), the Science and Technology Program of Guangdong Province (2017A050506027, 2017B090912005) and the Science and Technology Program of Guangzhou (201807010053).Weitere Informationen
Publikationsverlauf
Received: 10. März 2020
Accepted after revision: 31. März 2020
Publikationsdatum:
21. April 2020 (online)
§ These authors contributed equally to this work.
Abstract
A novel and efficient iron(III)-catalyzed regioselective C-3 sulfenylation of imidazo[1,2-a]pyridines with thiols under oxygen atmosphere has been developed. The reaction proceeds in moderate to good yields with a broad range of substrates, providing a novel, efficient and green route for accessing synthetically useful C3-sulfenated imidazo-[1,2-a]pyridines. Moreover, the fluoride-containing C3-sulfenated imidazo-[1,2-a]pyridine 3ai exhibited superior anticancer activity and good safety profiles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690903.
- Supporting Information
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