Synthesis of 5-Fluoroaminobenzothiazoles

Pooja Sharma; Gurdial Singh; Bhoomendra A. Bhongade; Malleshappa N. Noolvi; Andanappa K. Gadad

doi:10.1055/s-0040-1707105

CC BY-NC-ND 4.0 · SynOpen 2020; 04(02): 23-32
DOI: 10.1055/s-0040-1707105

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This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) (2020) The Author(s)

Synthesis of 5-Fluoroaminobenzothiazoles

Pooja Sharma

^aDepartment of Chemistry, The University of The West Indies, St. Augustine, Trinidad and Tobago Email: gurdial.singh@sta.uwi.edu

,

Gurdial Singh ∗

^aDepartment of Chemistry, The University of The West Indies, St. Augustine, Trinidad and Tobago Email: gurdial.singh@sta.uwi.edu

,

Bhoomendra A. Bhongade

^aDepartment of Chemistry, The University of The West Indies, St. Augustine, Trinidad and Tobago Email: gurdial.singh@sta.uwi.edu

^bRAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah, UAE

,

Malleshappa N. Noolvi

^cShree Dhanvantary Pharmacy College, Surat, Gujarat, India

,

Andanappa K. Gadad

^dSchool of Pharmacy, Faculty of Medical Sciences, The University of The West Indies, Mount Hope, Trinidad and Tobago

› Author Affiliations

Abstract

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Abstract

A series of 5-fluoro-2-(N-substituted)aminobenzothiazoles were synthesized by intramolecular cyclisation of the corresponding thioureas, which were prepared by treatment of 4-substituted 3-fluoroanilines with appropriate isothiocyanates.

Key words

synthetic methods - 2-aminobenzothiazoles - isothiocyanates - chiral - fluoro - heterocyclic

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References

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