Umbilical Cord Blood Lead Level Disparities between Flint and Detroit

Mona Hanna-Attisha; Ashweena Gonuguntla; Nadine Peart; Jenny LaChance; D. Kay Taylor; Sanjay Chawla

doi:10.1055/s-0040-1705135

American Journal of Perinatology, Table of Contents

Am J Perinatol 2021; 38(S 01): e26-e32
DOI: 10.1055/s-0040-1705135

Original Article

Umbilical Cord Blood Lead Level Disparities between Flint and Detroit

Mona Hanna-Attisha

¹Pediatric Residency Program, Hurley Children's Hospital at Hurley Medical Center, Flint, Michigan

²Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Flint, Michigan

,

Ashweena Gonuguntla

²Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Flint, Michigan

³Newborn Nursery, Hurley Children's Hospital at Hurley Medical Center, Flint, Michigan

,

Nadine Peart

¹Pediatric Residency Program, Hurley Children's Hospital at Hurley Medical Center, Flint, Michigan

²Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Flint, Michigan

,

Jenny LaChance

⁴Research, Hurley Medical Center, Flint, Michigan

⁵Office of Medical Education Research and Development, Michigan State University College of Human Medicine, East Lansing, Michigan

,

D. Kay Taylor

⁴Research, Hurley Medical Center, Flint, Michigan

⁵Office of Medical Education Research and Development, Michigan State University College of Human Medicine, East Lansing, Michigan

,

Sanjay Chawla

⁶Department of Pediatrics, Hutzel Women's Hospital and Children's Hospital of Michigan, Wayne State University, Detroit, Michigan

› Author Affiliations

Abstract

Objective The lead-in-water impact of the Flint water crisis on the youngest and most neurodevelopmentally vulnerable population was largely unknown. The objective of this study was to investigate and compare cord blood lead levels (CBLLs) in newborns in Flint, Michigan, after the Flint water crisis, to a group of Detroit newborns.

Study Design Mothers of 99 Flint newborns were surveyed about potential lead exposures. These neonates were born after the recognition of population-wide lead-in-water contamination. CBLLs were measured and maternal–fetal metrics were reviewed. CBLLs and maternal–fetal metrics were then compared with those of a retrospective cohort of 116 Detroit newborns who previously shared the same water source. Analysis involved descriptive statistics, independent t-test, and χ ² analysis.

Results CBLLs greater than or equal to 1 μg/dL (0.05 μmol/L) were more prevalent among Flint newborns (14%), as compared with Detroit newborns (2%; p = 0.001). This was a sevenfold disparity between Flint and Detroit newborns. No statistically significant differences were found in birth weight, head circumference, small for gestational age status, gestational age, or preterm status among the two groups.

Conclusion The Flint water crisis potentially exposed newborns to lead in utero, implicating maternal–fetal outcomes and future health and development. Primary prevention efforts, including identification and mitigation of lead exposure before conception and during pregnancy, are needed. New environmental exposure detection methods and long-term neurodevelopmental follow-up will complement the findings of this study.

Keywords

lead - newborn - infant - maternal–fetal health - cord blood - public health - Flint

Full Text

References

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