Physicochemical Characterization of Dynamized Solid Drugs
05 February 2020 (online)
Homeopathic medicine is defined as the pharmaceutical form obtained by the method of dilutions followed by successive succussions or crushing. Clinical homeopathic results have proven the efficacy of these drugs by different experimental models. However, with regard to the dynamics of solid systems, scientific knowledge is still very undeveloped.
In this context, in 2013, a Multicentric Project (Brazil-Italy) was started with the objective of expanding the studies of this system using dynamized solid systems prepared with metallic zinc in lactose (ZnMet). In this way, the present work evaluated the physical-chemical and structural changes resulting from the trituration process. The X-ray diffraction results indicated no changes in the crystalline structure of the lactose after the grinding process and also the presence of the zinc signal in the first potency (ZnMet 1dH).
Evaluation of differential exploratory calorimetry data shows that both the presence of zinc and the dynamization process alter the enthalpy values of the solid system as well as the dehydration temperature. In the Raman spectroscopy analysis, the amplitude and area of ZnMet (3 dH and 6 dH) samples were observed, especially in the region with the highest truss vibration (from 200 cm−1 to 500 cm−1).
In the infrared spectroscopy analyses, a decrease in signal intensity due to the dynamization process and the presence of zinc was observed, suggesting the formation of a complex between the metal and lactose. The scanning electron microscopy evaluation showed small particles with rough appearance on the lactose surface, indicating the adsorption of zinc to lactose.
This set of results suggests that the presence of zinc and the grinding process alter the enthalpy, polarization and vibration of chemical bonds of the dynamized solid system, and these methodologies are sensitive enough to characterize these homeopathic systems.
Keywords: Physical-chemistry, Homeopathy, Zinc, lactose, dynamization