Homeopathic Immunotherapy against Cancer

Introduction: Our research team at Federal University has studied, in vitro and in vivo, cancer cells treated with homeopathy in the last 20 years. After using different products and analysing the different results carefully, we arrived at two complexes produced with homeopathic techniques, coded as M1 and M8. The results obtained using these two products were surprising and some were published in scientific journals with good impact.

Methods and Results: The most appropriate and diverse methodology was used, with several controls: Confocal, Histochemistry, Electron Microscopy, Flow Cytometry, Slide Scanner, Matrigel matrix invasion, ImageJ software, etc. Our studies, in vitro and in vivo, have demonstrated that the medicines M1 and M8: prevented lung and subcutaneous melanoma growth; decreased angiogenesis inside tumors (p < 0.01); decreased some extracellular matrix molecules, such as perlecan and hyaluronic acid, decreasing metastasis (in Transwell plates, p < 0.01); activated macrophages, that can activate other cells in the immune system as well as endothelial cells and fibroblasts; modulated cytokines such as TNFα, IFNγ and IL10; increased not only the differentiation of NK cells (in flow cytometer, p < 0.001) but also the cytotoxicity of NK cells (p < 0.05); modulated reactive oxygen species (ROS) and nitric oxide (NO) production.

Conclusions: M1 and M8 are homeopathic complex medicines with immunomodulatory properties, without toxicity or mutagenic effects. This homeopathic immunotherapy can gently restore the immune system to recognize tumor cells; thus, they can be used to help in all cancer immune-phenotypes without acting on a specific molecular target and without toxicity, since the self-healing is stimulated through the immune system. However, the absence of clinical trials has limited their extensive use in cancer immunotherapy, despite the promising results in vitro as well as in vivo. Moreover, because in homeopathy we do not have a molecule to track, there is an impediment to further progress with these medicines without greater understanding of their physiological mechanism of action.

Keywords: Cancer, immunotherapy, homeopathic complexes, immune system