Semin Respir Crit Care Med 2020; 41(01): 042-052
DOI: 10.1055/s-0039-3400998
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pulmonary Coccidioidomycosis

Kathryn E. Kimes*
1  Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, Arizona
,
Sabirah N. Kasule*
2  Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona
,
Janis E. Blair
1  Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, Arizona
› Author Affiliations
Further Information

Publication History

Publication Date:
30 January 2020 (online)

Abstract

Coccidioidomycosis is an infection caused by the geographically restricted dimorphic fungus, Coccidioides. Coccidioidomycosis occurs endemically in the southwestern and western United States, mainly in focused regions of Arizona and California where the incidence is highest, and in Central and South America. Patients with impaired immunity, especially those with impaired cellular immunity, are at higher risk of severe and disseminated disease. In this review, we describe the fungal ecology and mycology, epidemiology, pathophysiology, and normal immune defenses to Coccidioides as well as address current concepts in diagnosis, treatment, and continued care of patients with pulmonary coccidioidomycosis. We also present and answer our most frequently asked questions regarding patients with primary pulmonary coccidioidomycosis.

* Co-first authors.