Thromb Haemost 2019; 19(10): 1563-1572
DOI: 10.1055/s-0039-1693702
Theme Issue Article
Georg Thieme Verlag KG Stuttgart · New York

MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Stefan Stojkovic
1  University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria
,
Anne Yaël Nossent
1  University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria
,
Paul Haller
2  3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria
,
Bernhard Jäger
2  3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria
3  Medical Faculty, Sigmund Freud University, Vienna, Austria
,
Kris G. Vargas
2  3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria
,
Johann Wojta
1  University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria
4  Core Facilities, Medical University of Vienna, Vienna, Austria
5  Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna Austria
,
Kurt Huber
2  3rd Department of Internal Medicine, Cardiology, Intensive Care Medicine and Chest Pain Unit, Wilhelminenhospital, Vienna, Austria
3  Medical Faculty, Sigmund Freud University, Vienna, Austria
› Author Affiliations
Further Information

Publication History

11 March 2019

12 June 2019

Publication Date:
17 August 2019 (eFirst)

Abstract

Microribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS.