TY - JOUR AU - Stojkovic, Stefan; Nossent, Anne Yaël; Haller, Paul; Jäger, Bernhard; Vargas, Kris G.; Wojta, Johann; Huber, Kurt TI - MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease SN - 0340-6245 SN - 2567-689X PY - 2019 JO - Thromb Haemost JF - Thrombosis and Haemostasis LA - EN VL - 119 IS - 10 SP - 1563 EP - 1572 ET - 2019/08/17 DA - 2019/09/29 KW - microRNA KW - platelet function KW - coronary artery disease KW - acute myocardial infarction KW - acute coronary syndrome AB - Microribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS. PB - Georg Thieme Verlag KG DO - 10.1055/s-0039-1693702 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1693702 ER -