Am J Perinatol 2019; 36(S 02): S110-S114
DOI: 10.1055/s-0039-1692133
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of Sustained Inflation or Positive Pressure Ventilation on the Release of Adrenomedullin in Preterm Infants with Respiratory Failure at Birth

Azzurra La Verde
1  Neonatal Intensive Care Unit, V. Buzzi Children's Hospital, ASST-FBF-Sacco, Milan, Italy
,
Simone Franchini
2  Neonatal Intensive Care Unit, G. D'Annunzio University of Chieti, Chieti, Italy
,
Giuseppe Lapergola
2  Neonatal Intensive Care Unit, G. D'Annunzio University of Chieti, Chieti, Italy
,
Gianluca Lista
1  Neonatal Intensive Care Unit, V. Buzzi Children's Hospital, ASST-FBF-Sacco, Milan, Italy
,
Ignazio Barbagallo
3  Department of Biomedical and Biotechnological Sciences Section of Biochemistry, University of Catania, Catania, Italy
,
Giovanni Livolti
3  Department of Biomedical and Biotechnological Sciences Section of Biochemistry, University of Catania, Catania, Italy
,
Diego Gazzolo
2  Neonatal Intensive Care Unit, G. D'Annunzio University of Chieti, Chieti, Italy
4  Department of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital Alessandria, Alessandria, Italy
› Author Affiliations
Funding This study is part of the I.O. PhD International Program, under the auspices of the Italian Society of Neonatology and of the Neonatal Clinical Biochemistry Research Group, and was partially supported by grants to Diego Gazzolo from “I Colori della Vita Foundation,” Italy.
Further Information

Publication History

Publication Date:
25 June 2019 (online)

Abstract

Objective Delivery room (DR) management may play an important role in the development and prevention of lung injury. Therefore, in a cohort of low birth weight infants (LBW), we investigated the effects of two different lung recruitment maneuvers, such as positive pressure ventilation (PPV) and sustained inflation (SI) on adrenomedullin (AM), a well-established lung-specific vasoactive agent.

Study Design This is a prospective case-control randomized study in 44 LBW infants spontaneously breathing with respiratory failure at birth requiring respiratory support. LBW were randomized to receive PPV (n = 22) or SI (n = 22) support. AM was measured from blood in samples collected at birth from arterial artery (BLT0) and at 1-hour (BLT1) and at 24-hour (BLT2) from peripheral venous site. AM assessment in urine samples was performed at 1-hour (URT1) and at 24-hour (URT2).

Results No significant differences in AM (p > 0.05) blood (T0–T2) and urine (T1, T2) levels were observed between groups.

Conclusion The present data, showing the absence of any differences in AM blood and urine levels, suggest that PPV and SI are both feasible and equally effective DR maneuvers. The findings open the way to further studies evaluating the effects of PPV and SI on short-/long-term respiratory outcome through biomarkers assessment.