Recent Advances in Photocatalytic Decarboxylative Coupling Reactions in Medicinal Chemistry

Lindsay McMurray; Thomas M. McGuire; Rachel L. Howells

doi:10.1055/s-0039-1690843

Synthesis, Table of Contents

Synthesis 2020; 52(12): 1719-1737
DOI: 10.1055/s-0039-1690843

review

Recent Advances in Photocatalytic Decarboxylative Coupling Reactions in Medicinal Chemistry

Authors

Lindsay McMurray∗

Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK Email: lindsay.mcmurray1@astrazeneca.com
Thomas M. McGuire
Rachel L. Howells

Abstract

All articles of this category

Abstract

This review covers recent advances in decarboxylative photocatalysis applicable to the medicinal chemist. The review is not intended to be exhaustive, but instead is focussed on transformations that could be useful in the synthesis of drug-like compounds in order to highlight the utility of this methodology in the development of new pharmaceutical candidates.

1 Introduction

2 C–C Bond Formation

3 C–N and C–O Bond Formation

4 Fluorination and Trifluoromethylation

5 Hydrodecarboxylation

6 Protein Functionalisation

7 Conclusion

Key words

decarboxylation - photocatalysis - photoredox - medicinal chemistry - late-stage functionalisation - drug discovery

Full Text

References

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