Advances in C(sp3)–H Bond Functionalization via Radical Processes

Tong Zhang; Yue-Hua Wu; Nai-Xing Wang; Yalan Xing

doi:10.1055/s-0039-1690674

Synthesis, Inhaltsverzeichnis

Synthesis 2019; 51(24): 4531-4548
DOI: 10.1055/s-0039-1690674

short review

Advances in C(sp³)–H Bond Functionalization via Radical Processes

Tong Zhang ‡

^aTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China eMail: nxwang@mail.ipc.ac.cn

,

Yue-Hua Wu ‡

^aTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China eMail: nxwang@mail.ipc.ac.cn

,

Nai-Xing Wang∗

^aTechnical Institute of Physics and Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China eMail: nxwang@mail.ipc.ac.cn

,

Yalan Xing∗

^bDepartment of Chemistry, William Paterson University of New Jers, New Jersey, 07470, USA eMail: xingy@wpunj.edu

› Institutsangaben

Abstract

Alle Artikel dieser Rubrik

‡ These authors contributed equally to this review.

Abstract

C(sp³)–H Bonds are the most common structures in organic molecules. In recent years, the direct functionalization of C(sp³)–H bonds has attracted wide attention and made significant progress. This review mainly focuses on C(sp³)–H bond functionalization of alkanes with or without functional groups via radical processes reported since 2017. In particular, three methods of generating free radicals are discussed: the use of a radical initiator such as TBHP or DTBP; photocatalysis, and via 1,5-hydrogen atom transfer (1,5-HAT).

1 Introduction

2 C(sp³)–H Bond Functionalization of Alkanes

3 C(sp³)–H Bond Functionalization of Alkanes with a Functional Group

4 Conclusions

Key words

C(sp³)–H functionalization - oxidative coupling - transition-metal catalyzed - step economy - green chemistry

Volltext

Referenzen

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