Abstract
Introduction This study was performed with the aim of detecting the interaction between cartilaginous
and bone tissues in the process of mandible morphogenesis in human embryos.
Material and Methods Whole-mount skeletal preparations, stained with Alcian blue and Alizarin red, as
well as serial histological sections impregnated with silver and stained with hematoxylin
and eosin were studied. A total of 48 human embryos/fetuses from 5 to 29 weeks of
age were used.
Results In the mandible anlage, in addition to the woven bone, cartilaginous and chondroid
tissues are present. Cartilaginous tissue islets are localized at the tip of the condylar
and coronoid processes and also in the region of the mandibular symphysis. The chondroid
tissue is incorporated into the bone in the region of the mandibular symphysis, along
the edge of the coronoid process, and also in the alveolar part of the mandible.
Conclusion Meckel’s cartilage participates in the formation of the mandibular body, and its
remains persist in the area of the mandibular symphysis until the second half of the
prenatal development.
Keywords
mandible - human development - Meckel’s cartilage - chondroid tissue - condylar cartilage
