Human Mandible Prenatal Morphogenesis

Abstract

Introduction This study was performed with the aim of detecting the interaction between cartilaginous and bone tissues in the process of mandible morphogenesis in human embryos.

Material and Methods Whole-mount skeletal preparations, stained with Alcian blue and Alizarin red, as well as serial histological sections impregnated with silver and stained with hematoxylin and eosin were studied. A total of 48 human embryos/fetuses from 5 to 29 weeks of age were used.

Results In the mandible anlage, in addition to the woven bone, cartilaginous and chondroid tissues are present. Cartilaginous tissue islets are localized at the tip of the condylar and coronoid processes and also in the region of the mandibular symphysis. The chondroid tissue is incorporated into the bone in the region of the mandibular symphysis, along the edge of the coronoid process, and also in the alveolar part of the mandible.

Conclusion Meckel’s cartilage participates in the formation of the mandibular body, and its remains persist in the area of the mandibular symphysis until the second half of the prenatal development.

Keywords

mandible - human development - Meckel’s cartilage - chondroid tissue - condylar cartilage

• References

• 1 Dhem A. The Mandible - Natural History of a Bone Completely Different from All the Others. Dental and Medical Problems 2004; 41 (03) 395-402
• 2 Collins P. 2015. Embryogenesis. In: Standring S. , ed. Gray's Anatomy E-Book: The Anatomical Basis of Clinical Practice. Philadelphia: Elsevier Limited; 32-226
• 3 Jaskoll T, Abichaker G, Sedghizadeh PP, Bringas Jr P, Melnick M. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol 2008; 8 (08) 33
• 4 Lee SK, Kim YS, Oh HS, Yang KH, Kim EC, Chi JG. Prenatal development of the human mandible. Anat Rec 2001; 263 (03) 314-325
• 5 Wyganowska-Świątkowska M, Przystańska A. The Meckel's cartilage in human embryonic and early fetal periods. Anat Sci Int 2011; 86 (02) 98-107
• 6 Amano O, Doi T, Yamada T. , et al. Meckel's cartilage: discovery, embryology and evolution: overview of the specificity of Meckel's cartilage. Journal of Oral Biosciences 2010; 52 (02) 125-135
• 7 Bontemps C, Cannistrà C, Hannecke V, Michel P, Fonzi L, Barbet JP. [The first appearance of Meckel's cartilage in the fetus]. Bull Group Int Rech Sci Stomatol Odontol 2001; 43 (03) 94-99
• 8 Radlanski RJ, Renz H, Zimmermann CA, Schuster FP, Voigt A, Heikinheimo K. Chondral ossification centers next to dental primordia in the human mandible: A study of the prenatal development ranging between 68 to 270mm CRL. Ann Anat 2016; 208: 49-57
• 9 Yang RT, Zhang C, Liu Y, Zhou HH, Li ZB. Autophagy prior to chondrocyte cell death during the degeneration of Meckel's cartilage. Anat Rec (Hoboken) 2012; 295 (05) 734-741
• 10 Hu Y, Wang Y, Luo Z, Li C. A new symmetrodont mammal from China and its implications for mammalian evolution. Nature 1997; 390 (6656): 137-142
• 11 Meng JIN, Hu Y, Wang Y, Li C. The ossified Meckel's cartilage and internal groove in Mesozoic mammalian forms: implications to origin of the definitive mammalian middle ear. Zool J Linn Soc 2003; 138 (04) 431-448
• 12 Ossenberg NS. The mylohyoid bridge: an anomalous derivative of Meckel's cartilage. J Dent Res 1974; 53 (01) 77-82
• 13 Yang L, Tsang KY, Tang HC, Chan D, Cheah KS. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci U S A 2014; 111 (33) 12097-12102
• 14 Leander D. Role of Growth Factors in the Development of Mandible. J Indian Orthod Soc 2011; 45 (02) 51-60
• 15 Mérida Velasco JR, Rodríguez Vázquez JF, De la Cuadra Blanco C, Campos López R, Sánchez M, Mérida Velasco JA. Development of the mandibular condylar cartilage in human specimens of 10-15 weeks' gestation. J Anat 2009; 214 (01) 56-64
• 16 Bailleul AM, Nyssen-Behets C, Lengelec B, Hall BK, Horner JR. Chondroid bone in dinosaur embryos and nestlings (Ornithischia: Hadrosauridae): Insights into the growth of the skull and the evolution of skeletal tissues. C R Palevol 2016; 15 (1–2): 49-64
• 17 El Fouhil AF. 2012. Development of the site of articulation between the two human hemimandibles (Symphysis Menti). In: Dr. Ken-Ichi Sato (ed). Embryogenesis, InTech 167-188
• 18 Habib H, Hatta T, Udagawa J, Zhang L, Yoshimura Y, Otani H. Fetal jaw movement affects condylar cartilage development. J Dent Res 2005; 84 (05) 474-479