Endoscopy 2019; 51(04): S245
DOI: 10.1055/s-0039-1681907
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STUDY OF CELIAC DISEASE SEROLOGY IN PATIENTS WITH JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS

AM Shamseya
1   Internal Medicine, University of Alexandria, Alexandria, Egypt
,
KA Abdelaty
1   Internal Medicine, University of Alexandria, Alexandria, Egypt
,
EH Elsayed
1   Internal Medicine, University of Alexandria, Alexandria, Egypt
,
HM Donia
2   Clinical & Chemical Pathology, University of Alexandria, Alexandria, Egypt
,
MM Shamseya
3   Experimental and Clinical Internal Medicine, University of Alexandria, Medical Research Institute, Alexandria, Egypt
,
AI Ellakany
4   Internal Medicine, University of Alexandria, Faculty of Medicine, Alexandria, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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Aims:

The aim was to screen patients with juvenile systemic lupus erythematosus for Celiac disease.

Methods:

100 patients with juvenile systemic lupus erythematosus were subjected to detailed history taking, Clinical examination with thorough joint examination Clinical assessment of lupus activity using SLEDAI score Serum levels of anti-tTG Ab IgA & IgG, esophagogastroduodenoscopy (EGD) for those with positive serology for Celiac disease.

Results:

Of the 100 recruited patients with juvenile systemic lupus erythematosus, 10 patients had positive serological evidence of Celiac disease. Of the 10 patients, 3 patients had mild elevation of IgG Anti Ttg (less than 20 U/ml), and seven patients had Serum levels of Anti-tTG more than 20 U/ml. Correlation of Serum Anti-tTG levels with SLEDAI score was positive (p < 0.05) denoting strong association between Celiac disease and activity of SLE. EGD was done to all 10 patients with positive serology for Celiac disease revealing six patients with manifest Celiac (positive serology & positive endoscopy/biopsy) and four cases of latent Celiac (positive serology & negative endoscopy/biopsy).

Conclusions:

From the results of the present study we conclude that the possibility of concomitant presence of both Celiac disease & SLE is high (10%). The masking of Celiac disease manifestations (intestinal & extra-intestinal) by SLE manifestations make diagnosis of Celiac disease missed in almost all cases and leaves screening for Celiac disease using serology as the gold standard for its detection among juvenile SLE patients.