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DOI: 10.1055/s-0039-1681222
HIGH DIAGNOSTIC ADEQUACY AND ACCURACY OF THE NEW 20G PROCORE NEEDLE FOR EUS-GUIDED TISSUE ACQUISITION: RESULTS OF A LARGE MULTICENTRE RETROSPECTIVE STUDY
Publication History
Publication Date:
18 March 2019 (online)
Aims:
EUS-guided fine-needle biopsy has become the standard for tissue sampling. A new 20G ProCore needle has been developed to overcome the limitations of tissue acquisition of the smaller needles (22G, 25G) and the rigidity of the larger one (19G). Aim of the study was to assess the performance of the 20G ProCore needle.
20G ProCore needle performance |
Pancreatic lesions (n = 236) |
Extra-pancreatic lesions (n = 148) |
Histological/cytological diagnosis drawn from tissue sample (diagnostic yield), n (%) |
218 (92.4%) |
141 (95.3%) |
Possibility to obtain histological core, n (%) |
170 (72.0%) |
125 (84.5%) |
Sensitivity for malignant lesions, % (95% CI) |
90.8% (86.1 – 94.3%) |
92.6% (85.4 – 97.0%) |
Specificity for malignant lesions, % (95% CI) |
100% (82.4 – 100%) |
100% (93.3 – 100%) |
Methods:
Patients who underwent EUS-guided tissue acquisition with the 20G ProCore needle of pancreatic and extra-pancreatic mass lesions were retrospectively identified at three Italian centers (Bologna, Fermo, Palermo). Diagnostic adequacy, accuracy and tissue core acquisition were the outcome measures. All the cases were performed without rapid on-site evaluation.
Results:
A total of 384 patients with pancreatic (62.2%) and extra-pancreatic lesions were included. For pancreatic lesions, adequacy, accuracy, sensitivity and specificity were 92.4%, 91.5%, 90.8% and 100%, respectively with a number needed to misdiagnose (NNM) of 11.8. The tissue core was obtained in 72% cases. Trans-duodenal approach was performed in 150 pancreatic lesions; adequacy, accuracy and tissue core acquisition were 88.7%, 90% and 66%, respectively (NNM 10). For extra-pancreatic lesions, adequacy, accuracy, sensitivity, specificity and tissue core sampling were 95.3%, 95.3%, 92.6%, 100% and 84.5% (NNM 21.3). Details are reported in Table 1.
Conclusions:
The 20G ProCore needle showed high diagnostic adequacy and accuracy, regardless of the access route.