SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson; John P. DeVincenzo; Eric A. F. Simões; Leonard R. Krilov; Michael L. Forbes; Pia S. Pannaraj; Claudia M. Espinosa; Robert C. Welliver; Leslie I. Wolkoff; Ram Yogev; Paul A. Checchia; Joseph B. Domachowske; Natasha Halasa; Scott J. McBride; Veena R. Kumar; Kimmie K. McLaurin; Christopher P. Rizzo; Christopher S. Ambrose

doi:10.1055/s-0039-1681014

American Journal of Perinatology, Table of Contents

CC BY-NC-ND 4.0 · Am J Perinatol 2020; 37(04): 421-429
DOI: 10.1055/s-0039-1681014

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson

¹Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia

,

John P. DeVincenzo

²Departments of Pediatrics and Microbiology, Immunology, and Biochemistry, University of Tennessee School of Medicine, Memphis, Tennessee

,

Eric A. F. Simões

³Section of Pediatric Infectious Disease, University of Colorado School of Medicine, Colorado School of Public Health, Children’s Hospital Colorado, Aurora, Colorado

,

Leonard R. Krilov

⁴Division of Pediatric Infectious Disease, Children's Medical Center, NYU-Winthrop Hospital, Mineola, New York

,

Michael L. Forbes

⁵Pediatric Critical Care Medicine, Akron Children's Hospital, Akron, Ohio

,

Pia S. Pannaraj

⁶Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, Keck School of Medicine, University of Southern California, Los Angeles, California

,

Claudia M. Espinosa

⁷Pediatric Infectious Diseases, University of Louisville, Louisville, Kentucky

,

Robert C. Welliver

⁸Pediatric Infectious Diseases, Children’s Hospital at OU Medical Center, Oklahoma City, Oklahoma

,

Leslie I. Wolkoff

⁹Division of Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut

,

Ram Yogev

¹⁰Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

,

Paul A. Checchia

¹¹Cardiac Intensive Care, Texas Children's Hospital, Houston, Texas

,

Joseph B. Domachowske

¹²Pediatrics: Infectious Disease, SUNY Upstate Medical University, Syracuse, New York

,

Natasha Halasa

¹³Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee

,

Scott J. McBride

¹⁴United BioSource Corporation, Ann Arbor, Michigan

,

Veena R. Kumar

¹⁵AstraZeneca, Gaithersburg, Maryland

,

Kimmie K. McLaurin

¹⁵AstraZeneca, Gaithersburg, Maryland

,

Christopher P. Rizzo

¹⁵AstraZeneca, Gaithersburg, Maryland

,

Christopher S. Ambrose

¹⁵AstraZeneca, Gaithersburg, Maryland

› Author Affiliations

Abstract

Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons.

Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1–April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized.

Results Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge.

Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.

Keywords

respiratory syncytial virus - infants - palivizumab - immunoprophylaxis - hospitalizations

Full Text

References

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Supplementary Material

Supplementary Material