Potential of Multidimensional, Large-scale Biodatabases to Elucidate Coagulation and Platelet Pathways as an Approach towards Precision Medicine in Thrombotic Disease

Abstract

Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale biodatabases. These important research resources enable a comprehensive research approach by integrating clinical, environmental, genomic, and molecular information. Cutting edge, high throughput technologies open new data dimensions for clinical large-scale investigations. Joining multiple information levels from several pathophysiological pathways in contrast to a single marker approach might better model the complexity of disease pathogenesis. This review focuses on the possibilities that ultimately allow conducting wide-scale analyses for unravelling the multifaceted interplay between coagulation and cellular (e.g., platelets) elements in the development of thrombotic disease. It further provides examples for the use of biodatabases in the field of venous thromboembolism, explores the links between venous and arterial thrombotic diseases, and finally informs on the current use of platelet biomarkers in the thrombosis and haemostasis field.

Zusammenfassung

Kardiovaskuläre und insbesondere thrombotische Erkrankungen sind nach wie vor eine der Hauptursachen für Morbidität und Mortalität weltweit. In den vergangenen Jahren wurden signifikante Verbesserungen hinsichtlich des Verständnisses von Krankheitsprozessen, der Risikobewertung und der Vorhersage des klinischen Ergebnisses auf dem Gebiet der Thrombose und Hämostase unter Verwendung von Biodatenbanken im großen Maßstab erzielt. Diese wichtigen Forschungsressourcen ermöglichen einen umfassenden Forschungsansatz, indem klinische, Umwelt-, Genom- und molekulare Informationen integriert werden. Spitzentechnologien mit hohem Durchsatz eröffnen neue Datendimensionen für klinische Großuntersuchungen. Das Zusammenfügen mehrerer Informationsebenen aus mehreren pathophysiologischen Wegen im Gegensatz zu einem einzelnen Marker kann die Komplexität der Pathogenese von Krankheiten besser modellieren. Diese Übersichtsarbeit konzentriert sich auf die Möglichkeiten, welche die Durchführung breit angelegter Analysen ermöglichen, um das vielfältige Wechselspiel zwischen Koagulation und zellulären (z. B. Blutplättchen) Elementen bei der Entwicklung einer thrombotischen Erkrankung aufzuklären. Sie bietet außerdem Beispiele für die Verwendung von Biodatenbanken im Bereich der Venenthromboembolie, untersucht die Verbindungen zwischen venösen und arteriellen thrombotischen Erkrankungen und informiert schließlich über die derzeitige Verwendung von Blutplättchen-Biomarkern im Bereich von Thrombose und Hämostase.

Keywords

epidemiology - biodatabase - coagulation - platelets

Schlüsselwörter

Epidemiologie - Biodatenbanken - Koagulation - Blutplättchen

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