Am J Perinatol 2019; 36(11): 1127-1135
DOI: 10.1055/s-0038-1676489
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study

Louopou Rosalie Camara
1   Social and Preventive Medicine Department, Public Health School, Université de Montréal, Quebec, Canada
2   Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada
,
Tye Elaine Arbuckle
3   Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
,
Helen Trottier
1   Social and Preventive Medicine Department, Public Health School, Université de Montréal, Quebec, Canada
2   Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada
,
William Donald Fraser
2   Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada
4   CHU Sherbrooke Research Center, Department of Obstetrics and Gynecology, Université de Sherbrooke, Sherbrooke, Quebec, Canada
› Author Affiliations
Funding The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (CIHR; grant MOP-81285), and the Ontario Ministry of the Environment. Author L.R.C. received a PhD scholarship from MIREC and QTNPR (Quebec Perinatal Research Training Network). Author H.T. holds a salary award (chercheur-boursier) from the Fonds de la recherche du Québec en santé (FRQ-S) and from CIHR (New investigator salary award). Author W.D.F. holds a Tier 1 CIHR Canada Research Chair.
Further Information

Publication History

22 June 2018

25 October 2018

Publication Date:
14 December 2018 (online)

Abstract

Background Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.

Objective To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension (GH) and preeclampsia.

Study Design Among 1,909 pregnant women participating in the maternal-infant research on environmental chemicals (MIREC) study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Blood pressure was measured during each trimester. Multinomial regression was performed to estimate the adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the associations between these phenols and GH and preeclampsia.

Results BPA and TCS were not associated with GH or preeclampsia. However, in multiparous women, BPA (0.50–1.30 µg/L) was associated with decreased risk of GH (aOR =0.45; 95%CI: 0.21–0.98) while among nulliparous women, TCS was associated with an increased risk of GH (3.60–32.60 µg/L; aOR = 2.58; 95% CI: 1.09–6.13 and > 32.60 µg/L: aOR = 2.74; 95% CI: 1.15–6.51).

Conclusion BPA and TCS urinary concentrations were not associated with GH or preeclampsia; however, our results suggest an association between TCS and GH in nulliparous women. Additional studies are required to confirm our results.

Supplementary Material