Download PDF
Am J Perinatol 2019; 36(10): 1039-1044
DOI: 10.1055/s-0038-1676114
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Interdelivery Interval and Diabetes Mellitus in a Subsequent Pregnancy

Annie M. Dude
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, Illinois
,
Ashley Battarbee
2   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
,
Lynn M. Yee
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, Illinois
› Author Affiliations Funding Research reported in this publication was supported, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. L.M.Y. is supported by the NICHD K12 HD050121-11. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Further Information

Publication History

06 September 2018

19 October 2018

Publication Date:
30 November 2018 (online)

    Permissions and Reprints

Abstract

Objective We determined whether time between deliveries is associated with developing diabetes at the time of a subsequent delivery.

Study Design This is a case–control study of women who had two consecutive singleton births at the same institution with no pregestational diabetes in the baseline pregnancy. Cases were defined as women who were diagnosed with any type of diabetes at the time of the subsequent delivery. Controls were defined as women who had no diagnosis of diabetes at the time of the subsequent delivery. Interdelivery interval (IDI) was categorized as < 18, 18 to 60, or > 60 months.

Results Of 12,263 women, 4.1% (N = 501) were diagnosed with diabetes at the subsequent delivery. Women with diabetes were more likely to have an IDI of >60 months than women without diabetes (9.0 vs. 4.2%, p < 0.001). After controlling for confounding factors, an IDI > 60 months remained associated with development of pregestational or gestational diabetes by the conclusion of the subsequent pregnancy (adjusted odds ratio = 2.13 compared with an IDI of 18–60 months, 95% confidence interval 1.44–3.15).

Conclusion A longer IDI is an independent risk factor for the development of diabetes at the time of a subsequent delivery.

Keywords

gestational diabetes - interdelivery interval - pregestational diabetes

Note

Portions of this article were presented at the 64th Annual Scientific Meeting of the Society for Reproductive Investigation, Orlando, FL, March 15–18, 2017, and the 15th Biannual Meeting of the Diabetes in Pregnancy Study Group of North America, Washington, DC, October 27–29, 2017.


 

  • References

  • 1 Committee on Practice Bulletins—Obstetrics. ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol 2018; 131 (02) e49-e64
    CrossrefPubMedGoogle Scholar
  • 2 Starikov R, Dudley D, Reddy UM. Stillbirth in the pregnancy complicated by diabetes. Curr Diab Rep 2015; 15 (03) 11
    CrossrefPubMedGoogle Scholar
  • 3 Admon LK, Winkelman TNA, Moniz MH, Davis MM, Heisler M, Dalton VK. Disparities in chronic conditions among women hospitalized for delivery in the United States, 2005-2014. Obstet Gynecol 2017; 130 (06) 1319-1326
    CrossrefPubMedGoogle Scholar
  • 4 Hauck YL, Lewis L, Nathan EA, White C, Doherty DA. Risk factors for severe perineal trauma during vaginal childbirth: a Western Australian retrospective cohort study. Women Birth 2015; 28 (01) 16-20
    CrossrefPubMedGoogle Scholar
  • 5 Kim SY, Kotelchuck M, Wilson HG, Diop H, Shapiro-Mendoza CK, England LJ. Prevalence of adverse pregnancy outcomes, by maternal diabetes status at first and second deliveries, Massachusetts, 1998-2007. Prev Chronic Dis 2015; 12: E218
    PubMedGoogle Scholar
  • 6 Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS. ; Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) Trial Group. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005; 352 (24) 2477-2486
    CrossrefPubMedGoogle Scholar
  • 7 Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009; 373 (9677): 1773-1779
    CrossrefPubMedGoogle Scholar
  • 8 Page KA, Romero A, Buchanan TA, Xiang AH. Gestational diabetes mellitus, maternal obesity, and adiposity in offspring. J Pediatr 2014; 164 (04) 807-810
    CrossrefPubMedGoogle Scholar
  • 9 Holmes HJ, Lo JY, McIntire DD, Casey BM. Prediction of diabetes recurrence in women with class A1 (diet-treated) gestational diabetes. Am J Perinatol 2010; 27 (01) 47-52
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Khambalia AZ, Ford JB, Nassar N, Shand AW, McElduff A, Roberts CL. Occurrence and recurrence of diabetes in pregnancy. Diabet Med 2013; 30 (04) 452-456
    CrossrefPubMedGoogle Scholar
  • 11 Ehrlich SF, Hedderson MM, Feng J, Davenport ER, Gunderson EP, Ferrara A. Change in body mass index between pregnancies and the risk of gestational diabetes in a second pregnancy. Obstet Gynecol 2011; 117 (06) 1323-1330
    CrossrefPubMedGoogle Scholar
  • 12 Xiang AH, Kjos SL, Takayanagi M, Trigo E, Buchanan TA. Detailed physiological characterization of the development of type 2 diabetes in Hispanic women with prior gestational diabetes mellitus. Diabetes 2010; 59 (10) 2625-2630
    CrossrefPubMedGoogle Scholar
  • 13 Hanley GE, Hutcheon JA, Kinniburgh BA, Lee L. Interpregnancy interval and adverse pregnancy outcomes: an analysis of successive pregnancies. Obstet Gynecol 2017; 129 (03) 408-415
    CrossrefPubMedGoogle Scholar
  • 14 Conde-Agudelo A, Rosas-Bermúdez A, Kafury-Goeta AC. Birth spacing and risk of adverse perinatal outcomes: a meta-analysis. JAMA 2006; 295 (15) 1809-1823
    CrossrefPubMedGoogle Scholar
  • 15 Yee LM, Truong YN, Caughey AB, Cheng YW. The association between interdelivery interval and adverse perinatal outcomes in a diverse US population. J Perinatol 2016; 36 (08) 593-597
    CrossrefPubMedGoogle Scholar
  • 16 ACOG Committee on Practice Bulletins. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Number 60, March 2005. Pregestational diabetes mellitus. Obstet Gynecol 2005; 105 (03) 675-685
    CrossrefPubMedGoogle Scholar
  • 17 Jain AP, Gavard JA, Rice JJ, Catanzaro RB, Artal R, Hopkins SA. The impact of interpregnancy weight change on birthweight in obese women. Am J Obstet Gynecol 2013; 208 (03) 205.e1-205.e7
    CrossrefPubMedGoogle Scholar
  • 18 Kjos SL, Peters RK, Xiang A, Thomas D, Schaefer U, Buchanan TA. Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus. JAMA 1998; 280 (06) 533-538
    CrossrefPubMedGoogle Scholar
  • 19 Feig DS, Zinman B, Wang X, Hux JE. Risk of development of diabetes mellitus after diagnosis of gestational diabetes. CMAJ 2008; 179 (03) 229-234
    CrossrefPubMedGoogle Scholar
  • 20 Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002; 25 (10) 1862-1868
    CrossrefPubMedGoogle Scholar
  • 21 Eades CE, Styles M, Leese GP, Cheyne H, Evans JM. Progression from gestational diabetes to type 2 diabetes in one region of Scotland: an observational follow-up study. BMC Pregnancy Childbirth 2015; 15: 11
    CrossrefPubMedGoogle Scholar
  • 22 Perritt JB, Burke A, Jamshidli R, Wang J, Fox M. Contraception counseling, pregnancy intention and contraception use in women with medical problems: an analysis of data from the Maryland Pregnancy Risk Assessment Monitoring System (PRAMS). Contraception 2013; 88 (02) 263-268
    CrossrefPubMedGoogle Scholar
  • 23 Schwarz EB, Braughton MY, Riedel JC. , et al. Postpartum care and contraception provided to women with gestational and preconception diabetes in California's Medicaid program. Contraception 2017; 96 (06) 432-438
    CrossrefPubMedGoogle Scholar
  • 24 Ahrens KA, Thoma M, Copen C, Frederiksen B, Decker E, Moskosky S. Unintended pregnancy and interpregnancy interval by maternal age, National Survey of Family Growth. Contraception 2018; 98 (01) 52-55
    CrossrefPubMedGoogle Scholar
  • 25 Getahun D, Fassett MJ, Jacobsen SJ. Gestational diabetes: risk of recurrence in subsequent pregnancies. Am J Obstet Gynecol 2010; 203 (05) 467.e1-467.e6
    CrossrefPubMedGoogle Scholar
  • 26 England L, Kotelchuck M, Wilson HG. , et al. Estimating the recurrence rate of gestational diabetes mellitus (GDM) in Massachusetts 1998–2007: methods and findings. Matern Child Health J 2015; 19 (10) 2303-2313
    CrossrefPubMedGoogle Scholar
  • 27 Peters RK, Kjos SL, Xiang A, Buchanan TA. Long-term diabetogenic effect of single pregnancy in women with previous gestational diabetes mellitus. Lancet 1996; 347 (8996): 227-230
    CrossrefPubMedGoogle Scholar
  • 28 Boghossian NS, Yeung E, Albert PS. , et al. Changes in diabetes status between pregnancies and impact on subsequent newborn outcomes. Am J Obstet Gyneco l 2014; 210 (05) 431.e1-431.e14
    PubMedGoogle Scholar