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Am J Perinatol 2019; 36(10): 1031-1038
DOI: 10.1055/s-0038-1676111
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Placenta Accreta: A Spectrum of Predictable Risk, Diagnosis, and Morbidity

Christina M. Duzyj
1   Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
,
Anne Cooper
2   Department of Obstetrics and Gynecology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island
,
Mohak Mhatre
3   Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts
,
Christina S. Han
4   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California
,
Michael J. Paidas
5   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut
6   Yale Women and Children's Center for Blood Disorders and Preeclampsia Advancement, New Haven, Connecticut
,
Jessica L. Illuzzi
5   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut
,
Anna K. Sfakianaki
5   Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut
› Author Affiliations
Funding Dr. Illuzzi's research in placenta accreta is supported by the Albert McKern Scholar Award for Perinatal Research.
Further Information

Publication History

25 September 2018

13 October 2018

Publication Date:
30 November 2018 (online)

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Abstract

Objective Placenta accreta is a feared pathology, in part, because prenatal diagnosis is imperfect. It is not known whether clinical risk factors or sonographic features equally predict the entire graded pathological spectrum of placental overinvasion disease nor whether clinical outcomes differ along the spectrum.

Study Design We conducted a mixed methods retrospective study of a cohort of women screened sonographically for placenta accreta, cross-referenced against cases identified by pathological diagnosis (N = 416). Demographic, diagnostic, and outcome information were compared across the spectrum of invasive placentation: percreta, increta, accreta, and focal accreta not requiring hysterectomy. The t-test, chi-square, Mann–Whitney, and Kruskal–Wallis tests were used for statistical analysis across groups.

Results As the depth of invasion decreased, risk factors for placental overinvasion were less common, especially placenta previa and previous cesarean. There was also reduced anticipation by sonographic examination of the placenta. Rates of adverse outcomes were lower among women with focal accreta compared with those with deeper invasion.

Conclusion As the depth of invasion decreases, clinical risk factors and sonographic evaluation are less reliable in the antenatal prediction of placenta accreta. The potential for unanticipated morbidity underscores the need for improved diagnostic tools for placenta accreta spectrum.

Keywords

placenta accreta - overinvasive placentation - placenta - retained placenta - ultrasound

Condensation

Placenta accreta is a disease spectrum, with poor predictability at a decreased depth of invasion based on clinical and sonographic factors, and reduced but persistent morbidity.


All research was performed at the Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT.