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Am J Perinatol 2019; 36(06): 624-631
DOI: 10.1055/s-0038-1672177
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Cande V. Ananth
1   Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Joseph L. Mailman School of Public Health, Columbia University, New York, New York
2   Department of Health Policy and Management, Joseph L. Mailman School of Public Health, Columbia University, New York, New York
,
Kathleen Jablonski
3   Department of Obstetrics and Gynecology, Biostatistics Center, The George Washington University, Washington, District of Columbia
,
Leslie Myatt
4   Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio
,
James M. Roberts
5   Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
,
Alan T. N. Tita
6   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
,
Kenneth J. Leveno
7   Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas
,
Uma M. Reddy
8   Pregnancy and Perinatal Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
,
Michael W. Varner
9   Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah
,
John M. Thorp Jr
10   Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
,
Brian M. Mercer
11   Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Alan M. Peaceman
12   Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois
,
Susan M. Ramin
13   Department of Obstetrics and Gynecology, Children's Memorial Hermann Hospital, The University of Texas Health Science Center at Houston, Houston, Texas
,
Marshall W. Carpenter
14   Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island
,
Philip Samuels
15   Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio
,
Anthony Sciscione
16   Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania
,
Jorge E. Tolosa
17   Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon
,
George Saade
18   Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
,
Yoram Sorokin
19   Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan
,
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network› Institutsangaben
Funding The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD34208, HD27869, HD40485, HD40560, HD40544, HD34116, HD40512, HD21410, HD40545, HD40500, HD27915, HD34136, HD27860, HD53118, HD53097, HD27917, and HD36801); the National Heart, Lung, and Blood Institute; and the National Center for Research Resources (M01 RR00080, UL1 RR024153, and UL1 RR024989). Comments and views of the authors do not necessarily represent the views of the NIH.
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Publikationsverlauf

06. März 2018

20. August 2018

Publikationsdatum:
03. Oktober 2018 (online)

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Abstract

Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s).

Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions.

Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00–1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12–2.13) and 1.35 (95% CI: 1.03–1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption.

Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

Keywords

ischemic placental disease - preeclampsia - placental abruption - small for gestational age infant - family history - inheritance

Note

In addition to the authors, other members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network are as follows:


Columbia University, New York, NY—R. Wapner, S. Bousleiman, R. Alcon, K. Saravia, F. Loffredo, A. Bayless (Christiana Care Health Systems, DE), C. Perez, M. Lake (St. Peter's University Hospital, NJ), M. Talucci.


University of Pittsburgh, Pittsburgh, PA—S. Caritis, T. Kamon (deceased), M. Cotroneo, D. Fischer.


University of Utah, Salt Lake City, UT—P. Reed, R. Silver, K. Hill (University of Utah), S. Quinn, F. Porter (LDS Hospital), V. Morby (McKay-Dee Hospital), J. Miller (Utah Valley Regional Medical Center).


University of Alabama at Birmingham, Birmingham, AL—J. Hauth, D.J. Rouse, A. Northen, P. Files, J. Grant, M. Wallace, K. Bailey.


University of North Carolina at Chapel Hill, Chapel Hill, NC—K. Boggess, K. Dorman, J. Mitchell, K. Clark, S. Timlin.


MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH—J. Bailit, C. Milluzzi, W. Dalton, C. Brezine, D. Bazzo.


University of Texas Southwestern Medical Center, Dallas, TX—J. Sheffield, L. Moseley, M. Santillan, K. Buentipo, J. Price, L. Sherman, C. Melton, Y. Gloria-McCutchen, B. Espino.


Northwestern University, Chicago, IL—M. Dinsmoor (NorthShore University Health System), T. Matson-Manning, G. Mallett.


Children's Memorial Hermann Hospital, The University of Texas Health Science Center at Houston, Houston, TX—S. Blackwell, K. Cannon, S. Lege-Humbert, Z. Spears.


Brown University, Providence, RI—J. Tillinghast, M. Seebeck.


The Ohio State University, Columbus, OH—J. Iams, F. Johnson, S. Fyffe, C. Latimer, S. Frantz, S. Wylie.


Drexel University, Philadelphia, PA—M. Talucci, M. Hoffman (Christiana), J. Benson (Christiana), Z. Reid, C. Tocci.


Wake Forest University Health Sciences, Winston-Salem, NC—M. Harper, P. Meis, M. Swain.


Oregon Health & Science University, Portland, OR—W. Smith, L. Davis, E. Lairson, S. Butcher, S. Maxwell, D. Fisher.


The University of Texas Medical Branch, Galveston, TX—J. Moss, B. Stratton, G. Hankins, J. Brandon, C. Nelson-Becker, G. Olson, L. Pacheco.


Wayne State University, Detroit, MI—G. Norman, S. Blackwell, P. Lockhart, D. Driscoll, M. Dombrowski.


The George Washington University Biostatistics Center, Washington, DC—E. Thom, R. Clifton, T. Boekhoudt, L. Leuchtenburg.


National Heart, Lung, and Blood Institute, Bethesda, MD—G. Pearson, V. Pemberton, J. Cutler, W. Barouch.


Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD—C. Spong, S. Tolivaisa.


MFMU Network Steering Committee Chair (The University of Texas Medical Branch, Galveston, TX)—G.D. Anderson.