Am J Perinatol 2019; 36(03): 252-257
DOI: 10.1055/s-0038-1667379
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Side Effects of Phototherapy on Neonates

Fabrízia R. S. Faulhaber
1   Postgraduate Program in Child Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
,
Renato S. Procianoy
1   Postgraduate Program in Child Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
3   Neonatal Section, Hospital de Clínicas de Porto Alegre, HCPA, Porto Alegre, Brazil
,
Rita C. Silveira
1   Postgraduate Program in Child Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
3   Neonatal Section, Hospital de Clínicas de Porto Alegre, HCPA, Porto Alegre, Brazil
› Author Affiliations
Further Information

Publication History

09 January 2018

02 July 2018

Publication Date:
06 August 2018 (online)

Abstract

Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years. Through this review, we seek to analyze what we know about the side effects of phototherapy in the neonatal period. The main causes of jaundice, phototherapy techniques, acute and late side effects, and effects on the immune and inflammatory system were reviewed. It was concluded that phototherapy is not a treatment free of side effects and further studies need to be conducted to elucidate its harmful effects on neonates.

 
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