Antenatal Magnesium Sulfate Exposure and Ponderal Index in Preterm Infants

Tiffany E. Deihl; Hyagriv N. Simhan

doi:10.1055/s-0038-1667375

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2019; 36(03): 329-334
DOI: 10.1055/s-0038-1667375

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Antenatal Magnesium Sulfate Exposure and Ponderal Index in Preterm Infants

Tiffany E. Deihl

¹Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee–Womens Hospital of UPMC, Pittsburgh, Pennsylvania

,

Hyagriv N. Simhan

²Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

› Institutsangaben

Abstract

Objective Antenatal magnesium sulfate (MgSO₄) is known to affect the central nervous system of preterm infants, and there is biologic rationale for influence on other phenotypes. This study investigated the effect of MgSO₄ exposure on the trajectory of ponderal index (PI, kg/m³) from birth to 2 years of age.

Study Design A secondary analysis of a U.S. randomized controlled trial investigating MgSO₄ versus placebo administration among women at high risk for preterm delivery was performed. Multivariable logistic regression was used to assess the relationship between PI from birth to 2 years of age and exposure to MgSO₄ versus placebo.

Results There was a larger decrement in PI from birth to 2 years of age in infants exposed to MgSO₄ compared with placebo (p = 0.032). There was a statistically significant one-way interaction between newborn sex and treatment group (p = 0.019). Change in PI in males exhibited a greater decrement in those exposed to MgSO₄ versus placebo (p = 0.227), whereas female infants exposed to MgSO₄ had a smaller decrement (p = 0.04).

Conclusion MgSO₄ exposure in preterm infants is associated with a larger decrease in PI from birth to 2 years of age. In addition, the direction of effect of MgSO₄ on the change in PI over the first 2 years of life is different by sex.

Keywords

preterm - magnesium sulfate - ponderal index - sex-specific difference

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