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Am J Perinatol 2019; 36(03): 329-334
DOI: 10.1055/s-0038-1667375
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Antenatal Magnesium Sulfate Exposure and Ponderal Index in Preterm Infants

Tiffany E. Deihl
1   Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee–Womens Hospital of UPMC, Pittsburgh, Pennsylvania
,
Hyagriv N. Simhan
2   Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
› Author Affiliations
Further Information

Publication History

13 March 2018

01 July 2018

Publication Date:
15 August 2018 (online)

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Abstract

Objective Antenatal magnesium sulfate (MgSO4) is known to affect the central nervous system of preterm infants, and there is biologic rationale for influence on other phenotypes. This study investigated the effect of MgSO4 exposure on the trajectory of ponderal index (PI, kg/m3) from birth to 2 years of age.

Study Design A secondary analysis of a U.S. randomized controlled trial investigating MgSO4 versus placebo administration among women at high risk for preterm delivery was performed. Multivariable logistic regression was used to assess the relationship between PI from birth to 2 years of age and exposure to MgSO4 versus placebo.

Results There was a larger decrement in PI from birth to 2 years of age in infants exposed to MgSO4 compared with placebo (p = 0.032). There was a statistically significant one-way interaction between newborn sex and treatment group (p = 0.019). Change in PI in males exhibited a greater decrement in those exposed to MgSO4 versus placebo (p = 0.227), whereas female infants exposed to MgSO4 had a smaller decrement (p = 0.04).

Conclusion MgSO4 exposure in preterm infants is associated with a larger decrease in PI from birth to 2 years of age. In addition, the direction of effect of MgSO4 on the change in PI over the first 2 years of life is different by sex.

Keywords

preterm - magnesium sulfate - ponderal index - sex-specific difference
 

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