Percutaneous Treatment with a Mucopolysaccharide Polysulphate of Experimentally Induced Subcutaneous Haematomas in Man

Summary

In a double blind trial on ten healthy volunteers, the efficacy of a topically applied mucopolysaccharide polysulphate[*] in the treatment of subcutaneous haematomas was assessed. Standardized haematomas were induced by subcutaneous injection of a mixture of autogenous blood and ¹²⁵I-fibrinogen. The absorption of the haematoma, expressed as the removal of the labelled fibrin(ogen), could thus be objectively measured by the decrease in radioactivity.

The results show an exponential absorption of these haematomas. The absorption time was reduced to about half compared with placebo, when treated topically with mucopolysaccharide polysulphate. The difference is statistically highly significant and is also considered clinically relevant.

Keywords

Haematoma absorption - ¹²⁵I-fibrinogen - Topical treatment

^*Hirudoid® cream, manufacturer Luitpold-Werk, Munich, FRG

^*Hirudoid® cream. Luitpold-Werk, Munich, FRG

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