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Thromb Haemost 1985; 53(03): 328-331
DOI: 10.1055/s-0038-1661308
Original Article
Schattauer GmbH Stuttgart

Persistence and Progression of Immunologic Abnormalities in Haemophilia

Joan C Gill
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
Dana Wheeler
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
Jay E Menitove
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
Richard H Aster
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
James T Casper
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
Phyllis Kirchner
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
,
Robert R Montgomery
The Blood Center of Southeastern Wisconsin, the Great Lakes Hemophilia Foundation, and the Departments of Pediatrics and Medicine, The Medical College of Wisconsin, Milwaukee, Wl, USA
› Author Affiliations
Further Information

Publication History

Received 08 October 1984

Accepted 27 February 1985

Publication Date:
18 July 2018 (online)

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Summary

Immunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2–7 occasions. Concentrate users had significantly decreased mean T4 (helper)/T8 (suppressor) lymphocyte ratios when the initial (1.5 ± .43) and most recent (1.25 ± .60) values were compared (p <.001), whereas in cryoprecipitate users mean values remained normal. Of the 22 concentrate users with initially normal T4/T8 ratios, 10 became abnormal during the study, an incidence of 45%. Fifteen of 28 (54%) patients with abnormal T4/T8 ratios had elevated circulating immune complexes (CIC), whereas all 16 patients with normal T4/T8 ratios had normal levels of CIC. Six patients have persistent lymphadenopathy.

Keywords

Haemophilia - Acquired immune deficiency - Immune complexes - Lymphocyte subsets - Therapeutic clotting factor replacement
 

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