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Thromb Haemost 1985; 53(03): 320-322
DOI: 10.1055/s-0038-1661306
Original Article
Schattauer GmbH Stuttgart

Protein C Deficiency – Response to Danazol and DDAVP

R Gonzalez
The Department of Haematology, University of Salamanca, Barcelona, Spain
,
I Alberca
The Department of Haematology, University of Salamanca, Barcelona, Spain
,
N Sala
1   The Hospital de la Santa Cruz y San Pablo, Barcelona, Spain
,
V Vicente
The Department of Haematology, University of Salamanca, Barcelona, Spain
› Author Affiliations
Further Information

Publication History

Received 24 September 1984

Accepted 20 February 1985

Publication Date:
21 August 2018 (online)

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Summary

We studied a Spanish family in which one of the female members presented recurrent thrombophlebitis in both legs after three different deliveries. Biological and antigenic activity of protein C was decreased (35% and 42% respectively). Reduced protein C levels were also observed in 6 other family members. Administration of danazol (600 mg/day) in two patients with protein C deficiency elevated this protein and discontinuation of the drug resulted in a reduction of protein C to pretreatment values. The proposita showed a normal fibrinolytic activity and infusion of DDAVP produced a similar response of FVIII/VWF and plasminogen activator to those observed in healthy subjects.

Keywords

Protein C deficiency - Recurrent thrombosis - Danazol - DDAVP
 

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