Thromb Haemost 1985; 53(03): 312-313
DOI: 10.1055/s-0038-1661304
Original Article
Schattauer GmbH Stuttgart

Identification of Platelet Inhibitor Present in the Melon (Cucurbitacea Cucumis Melo)

Raul Altman
1   The Centro de Estudios Medicos y Bioquimicos, Buenos Aires, Argentina
,
Jorge Rouvier
1   The Centro de Estudios Medicos y Bioquimicos, Buenos Aires, Argentina
,
Hans Weisenberger
2   Dr. K. Thomae GmbH, Biberach/Riss, West Germany
› Author Affiliations
Further Information

Publication History

Received 23 October 1984

Accepted 14 February 1985

Publication Date:
18 July 2018 (online)

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Summary

An active fraction was isolated from an aqueous melon extract (Cucurbitacea cucumis melo) and was shown that it inhibits human platelet aggregation induced by epinephrine, ADP, collagen, thrombin, sodium arachidonate, prostaglandin endoperoxide analogue U-46619 and PAF-acether. Identification of the active substance as adenosine was indicated by TLC which gave identical Rf value compared to adenosine, by the UV spectrum, because the inhibitory effect on platelet aggregation disappeared after the addition of adenosine-deaminase and because the substance under study and adenosine produced the same spectra in the mass spectroscopy.