Thromb Haemost 1984; 51(03): 313-316
DOI: 10.1055/s-0038-1661090
Original Article
Schattauer GmbH Stuttgart

Effect of Vitamin E on Platelet Aggregation in Diabetes Mellitus

J Watanabe
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
,
F Umeda
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
,
H Wakasugi
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
,
H Ibayashi
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
› Author Affiliations
Further Information

Publication History

Received 09 September 1983

Accepted 08 February 1984

Publication Date:
19 July 2018 (online)

Summary

Vitamin E is known to be an inhibitor of platelet prostaglandin production and aggregation. The rate of platelet aggregation induced by adenosine diphosphate was significantly increased in diabetics with proliferative retinopathy and the enhanced production of thromboxane B2, a stable metabolite of thromboxane A2, was demonstrated in those patients. On the other hand, vitamin E in platelets was significantly reduced in diabetics compared with age matched controls. In addition, it was shown that vitamin E content in platelets examined in diabetic and control subjects inversely correlated with both the rate of platelet aggregation and thromboxane B2 production during aggregation. It is suggested that the reduced vitamin E levels in diabetic platelets can contribute to the mechanisms of the enhanced platelet thromboxane production and aggregation which relate to the development of vascular complications.

 
  • References

  • 1 Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976; 295: 369-377-420-425
  • 2 Bensoussan D, Levy-Toledano S, Passa P, Caen J, Canivet J. Platelet hyperaggregation and increased plasma level of von Willebrand factor in diabetic retinopathy. Diabetologia 1976; 11: 307-312
  • 3 Colwell JA, Winocour PD, Halushka PV. Do platelets have anything to do with diabetic microvascular disease. Diabetes 1983; 32 suppl (Suppl. 02) 14-19
  • 4 Kwaan HC, Colwell JA, Cruz S, Suwanwela N, Dobbie JG. Increased platelet aggregation in diabetes mellitus. J Lab Clin Med 1972; 80: 236-246
  • 5 Colwell JA, Raghavan MG N, Halushka PV, Rogers C, Whetsell A, Sagel J. Platelet adhesion and aggregation in diabetes mellitus. Metabolism 1979; 28: 394-400
  • 6 Umeda F, Adnot S, Franks DJ, Hamet P. Cyclic nucleotide phosphodiesterase and aggregation in platelets from diabetic rats. Metabolism 1982; 31: 704-709
  • 7 Sugimoto H, Kimura T, Wakasugi H, Ibayashi H. Metabolic changes of prostaglandins in diabetic rats and restoration by insulin therapy. Fukuoka Acta Medica 1982; 73: 76-83
  • 8 Fong JS C. Alpha-tocopherol: its inhibition on human platelet aggregation. Experientia 1976; 15: 639-641
  • 9 Steiner M, Anastasi J. Vitamin E: an inhibitor of the platelet release reaction. J Clin Invest 1976; 57: 732-737
  • 10 Karpen CW, Merola AJ, Trewyn RW, Cornwell DG, Panganamala RV. Modulation of platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E. Prostaglandins 1981; 22: 651-661
  • 11 Born GV R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-929
  • 12 Siess W, Roth P, Weber PC. Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation. Thromb Haemostas 1981; 45: 204-207
  • 13 Thompson JN, Erdody P, Maxwell WB. Simultaneous fluorometric determinations of vitamin A and E in human serum and plasma. Biochem Med 1973; 8: 403-414
  • 14 Halushka PV, Rogers RC, Loadholt CB, Colwell JA. Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med 1981; 97: 87-96
  • 15 Karpen CW, Pritchard KA, Arnold JH, Cornwell DG, Panganamala RV. Restoration of prostacyclin/thromboxane A2 balance in the diabetic rat: influence of dietary vitamin E. Diabetes 1982; 31: 947-951
  • 16 Butler AM, Gerrard JM, Peller J, Stoddard SF, Rao GH R, White JG. Vitamin E inhibits the release reaction of calcium from a platelet membrane fraction in vitro. Prostaglandins Med 1979; 2: 203-216
  • 17 Panganamala RV, Cornwell DG. The effects of vitamin E on arachidonic acid metabolism. Ann N Y Acad Sci 1982; 393: 376-391
  • 18 Sugimoto H, Matsumoto M, Kimura T, Ibayashi H. The effects of vitamin E on prostaglandin metabolism. Plasma lipoperoxide and aortic prostacyclin production in vitamin E deficient rats J Japan Artheriosclerosis Soc 1980; 8: 575-578