Thromb Haemost 1985; 54(03): 619-621
DOI: 10.1055/s-0038-1660083
Original Article
Schattauer GmbH Stuttgart

Aspirin and the Prevention of Experimental Arterial Thrombosis: Difficulty in Establishing Unequivocal Effectiveness

Ine Reyers
1   The Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
,
Adje Hennissen
2   The Department of Human Biology, Rijksuniversiteit Limburg, Maastricht, The Netherlands
,
Maria Benedetta Donati
1   The Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
,
Gerard Hornstra
3   The Department of Biochemistry, Rijksuniversiteit Limburg, Maastricht, The Netherlands
,
Giovanni de Gaetano
1   The Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
› Author Affiliations
Further Information

Publication History

Received 07 December 1985

Accepted 27 July 1985

Publication Date:
19 July 2018 (online)

Summary

A trial of the efficacy of aspirin in the prevention of thrombotic occlusion of an “aortic loop” in rats was made simultaneously by two experimental surgeons. A relatively large dose of aspirin (80-100 mg/kg/day) was used, starting two days before operation. It appeared that aspirin was of limited benefit, reducing thrombotic occlusions by about 17% seven days after the insertion of the loop into the abdominal aorta. Although the average occlusion time was prolonged by about 17% in aspirin-treated animals, the separate trials gave no conclusive result. When the data from both operators were pooled, a statistically significant protection by aspirin was apparent (p = 0.02), by a two-tailed Student’s t test. However, on using the powerful non-parametric randomization test, the occlusion times in control and aspirin-treated groups appeared not statistically different (p = 0.07). No significant difference was also found between control and treated groups when data were analyzed by X2 test. Independently of the statistical analysis, these data are quite similar to those obtained from aspirin trials in men surviving myocardial infarction. This finding points to the usefulness of the aorta loop as an animal model for arterial thrombosis.

 
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