Summary
The production of prostacyclin by rat aortic rings was measured following administration
of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion
over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had
no effect on prostacyclin production by rat aortic rings in comparison with controls.
However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54
g/ml of nicotine at the rate of 1 μl per hour produced significantly less prostacyclin
than control animals.
Keywords
Nicotine - Prostacyclin - Endothelium
