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Thromb Haemost 1985; 54(02): 472-474
DOI: 10.1055/s-0038-1657876
Original Article
Schattauer GmbH Stuttgart

The Effects of Nicotine on PGI2 Production by Rat Aortic Endothelium

Authors

  • H A Bull

    The Middlesex Hospital Medical School, London, UK

  • R M Pittilo

    *   The Departments of Haematology and Histopathology, London, UK

  • D J Blow

    *   The Departments of Haematology and Histopathology, London, UK

  • C M Blow

    *   The Departments of Haematology and Histopathology, London, UK

  • P M Rowles

    *   The Departments of Haematology and Histopathology, London, UK

  • N Woolf

    *   The Departments of Haematology and Histopathology, London, UK

  • S J Machin

    The Middlesex Hospital Medical School, London, UK
Further Information

Publication History

Received 29 January 1985

Accepted 17 May 1985

Publication Date:
18 July 2018 (online)

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Summary

The production of prostacyclin by rat aortic rings was measured following administration of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had no effect on prostacyclin production by rat aortic rings in comparison with controls. However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54 g/ml of nicotine at the rate of 1 μl per hour produced significantly less prostacyclin than control animals.

Keywords

Nicotine - Prostacyclin - Endothelium